IMMUNOLOGICAL RELATIONSHIPS DURING PRIMARY INFECTION WITH HELIGMOSOMOIDES-POLYGYRUS (NEMATOSPIROIDES-DUBIUS) - DOWN-REGULATION OF SPECIFIC CYTOKINE SECRETION (IL-9 AND IL-10) CORRELATES WITH POOR MASTOCYTOSIS AND CHRONIC SURVIVAL OF ADULT WORMS
IMMUNOLOGICAL RELATIONSHIPS DURING PRIMARY INFECTION WITH HELIGMOSOMOIDES-POLYGYRUS (NEMATOSPIROIDES-DUBIUS) - DOWN-REGULATION OF SPECIFIC CYTOKINE SECRETION (IL-9 AND IL-10) CORRELATES WITH POOR MASTOCYTOSIS AND CHRONIC SURVIVAL OF ADULT WORMS
复制标题
DOI：
10.1111/j.1365-3024.1993.tb00626.x
复制
发表时间：
1993-07-01
影响因子：
2.2
通讯作者：
GOYAL, PK
中科院分区：
文献类型：
--
作者：
BEHNKE, JM;WAHID, FN;GOYAL, PK
小鼠感染旋毛虫（第 0 天）、多回旋毛虫（第 14 天）或同时感染这两种物种，并与初始对照小鼠一起分组处死 2 次（感染旋毛虫后第 8 和 15 天，相当于感染旋毛虫后第 22 和 29 天）。在同时感染的小鼠中，旋毛虫的排出显着减慢，这与肥大细胞增多症减少和血清粘膜肥大细胞蛋白酶水平降低有关。当伴刀豆球蛋白 A (Con-A) 体外刺激时，所有三个实验组的肠系膜淋巴结 (MLN) 淋巴细胞均分泌大量 IL-3 和 IL-4，但高水平 IL-9 和 IL-10 的分泌基本上仅限于仅感染旋毛虫的小鼠。研究表明，成体多回菌在感染过程中选择性调节 MLN 内 Th2 细胞的细胞因子分泌，这是多回菌抑制粘膜炎症反应以促进其自身生存的机制的直接结果。
Mice were infected either with Trichinella spiralis (day 0), Heligmosomoides polygyrus (day - 14) or concurrently with both species and were killed in groups, together with naive control mice, on 2 occasions (day 8 and 15 post infection with T. spiralis, corresponding to days 22 and 29 p.i. with H. polygyrus). The expulsion of T. spiralis was slowed significantly in concurrently infected mice and this was associated with a reduced mastocytosis and lower serum mucosal mast cell protease levels. Mesenteric lymph node (MLN) lymphocytes from all three experimental groups secreted IL-3 and IL-4 in copious amounts when stimulated in vitro by Concanavalin A (Con-A), but the secretion of high levels of IL-9 and IL-10 was essentially confined to mice infected with T. spiralis alone. It is suggested that adult H. polygyrus selectively modulate cytokine secretion by Th2 cells within the MLN during infection and that this is brought about as a direct consequence of the mechanism employed by H. polygyrus to depress mucosal inflammatory responses in order to facilitate its own survival.