Vaccinia virus DNA replication: A short review
Vaccinia virus DNA replication: A short review
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DOI：
10.1016/0300-9084(96)88195-8
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发表时间：
1995-01-01
期刊：
影响因子：
3.9
通讯作者：
Beaud, G
中科院分区：
文献类型：
--
作者：
Beaud, G
本文综述了自1990年以来关于痘病毒DNA复制、重组和修复的研究进展。温度敏感性突变揭示了与病毒DNA复制相关的四个必需基因：E9L DNA聚合酶、B1R蛋白激酶、D5R蛋白和D4R尿嘧啶DNA糖基化酶。其他蛋白质也可能参与病毒DNA复制：H6R DNA拓扑异构酶，131，单链DNA结合蛋白，H5R病毒体相关蛋白和A50R DNA连接酶。此外，几种病毒编码的蛋白质确实调节脱氧核糖核苷三磷酸库的水平：J2R胸苷激酶、A48R胸苷酸激酶、核糖核苷酸还原酶的I4L和F4L亚基以及F2L dUTR。尽管牛痘病毒DNA复制的机制明显简单，但与三个R相关的几个重要问题仍然没有解决。
The purpose of this review is to summarize information published since 1990 on DNA replication, recombination and repair of vaccinia virus, a poxvirus. Temperature-sensitive mutations reveal four essential genes related to viral DNA replication: the E9L DNA polymerase, B1R protein kinase, D5R protein, and D4R uracil DNA glycosylase. Other proteins are likely to be also involved in viral DNA replication: the H6R DNA topoisomerase, 131, single stranded-DNA binding protein, H5R virosome-associated protein, and A50R DNA ligase. In addition, several viral-encoded proteins do regulate the level of the deoxyribonucleoside triphosphate pool: the J2R thymidine kinase, A48R thymidylate kinase, I4L and F4L subunits of ribonucleotide reductase, and F2L dUTPase. Despite the apparent simplicity of the mechanism of vaccinia virus DNA replication several important questions related to the three Rs remain unsolved.