Airway epithelial cells, cytokines, and pollutants
Airway epithelial cells, cytokines, and pollutants
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DOI：
10.1164/ajrccm.160.supplement_1.11
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发表时间：
1999-11-01
影响因子：
24.7
通讯作者：
Devalia, JL
中科院分区：
文献类型：
--
作者：
Mills, PR;Davies, RJ;Devalia, JL
气道上皮是一个复杂的物理化学屏障，在宿主防御中起着关键作用。上皮细胞已被证明是几类调节化合物的丰富来源，其中细胞因子形成最大的组，并可能在气道疾病的病因学中发挥最重要的作用。有证据表明，有呼吸道疾病和无呼吸道疾病的个体的气道上皮细胞存在差异，这两个方面均涉及（1）它们表达和释放不同类型和数量的特定细胞因子的能力和（2）它们对吸入刺激物的反应性。因此，很容易推测上皮细胞功能的差异是呼吸道疾病易感性的重要决定因素。然而，这些差异是否是内在缺陷的结果，由于疾病过程本身而获得的属性，或两者的组合，仍有待确定。鉴于在理解气道疾病中假定的潜在机制方面已经取得的进展，应该可以以针对特异性促炎细胞因子的特异性单克隆抗体的形式配制新型治疗剂。
The airway epithelium is a complex physicochemical barrier that plays a pivotal role in host defense. Epithelial cells have been shown to be a rich source of several classes of modulatory compounds, of which the cytokines form the largest group and possibly play the most important role in the etiology of airway disease. Evidence suggests that there are differences in the airway epithelial cells of individuals with and without respiratory disease, both with regard to (1) their capacity to express and release different types and quantities of specific cytokines and (2) their reactivity to inhaled irritants. Consequently, it is tempting to speculate that differences in epithelial cell function are an Important determinant of the predisposition to respiratory disease. However, whether the differences are a result of an intrinsic defect, an acquired property due to the disease process itself, or a combination of the two, remains to be determined. In view of advances that have been made in the understanding of the putative underlying mechanisms in airway diseases, it should be possible to formulate novel therapeutic agents in the form of specific monoclonal antibodies directed against specific proinflammatory cytokines.