Impaired bone healing in multitrauma patients is associated with altered leukocyte kinetics after major trauma
Impaired bone healing in multitrauma patients is associated with altered leukocyte kinetics after major trauma
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DOI：
10.2147/jir.s101064
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发表时间：
2016-01-01
影响因子：
4.5
通讯作者：
Blokhuis, Taco J.
中科院分区：
文献类型：
--
作者：
Bastian, Okan W.;Kuijer, Anne;Blokhuis, Taco J.
动物研究表明，对严重损伤的全身炎症反应损害骨再生。目前尚不清楚全身免疫反应是否有助于损伤骨折愈合的多发伤患者。众所周知，严重创伤后的全身炎症变化会影响白细胞动力学。因此，我们回顾性地比较了胫骨骨折愈合正常（n=48）和受损（n=32）的多发伤患者在受伤后前2周外周血的细胞组成。在创伤后的前2周内，骨折愈合正常和受损的患者之间的白细胞、中性粒细胞、单核细胞和血小板的外周血计数曲线存在显著差异（P值分别为0.0122、0.0083、0.0204和0.0205）。
Animal studies have shown that the systemic inflammatory response to major injury impairs bone regeneration. It remains unclear whether the systemic immune response contributes to impairment of fracture healing in multitrauma patients. It is well known that systemic inflammatory changes after major trauma affect leukocyte kinetics. We therefore retrospectively compared the cellular composition of peripheral blood during the first 2 weeks after injury between multitrauma patients with normal (n=48) and impaired (n=32) fracture healing of the tibia. The peripheral blood-count curves of leukocytes, neutrophils, monocytes, and thrombocytes differed significantly between patients with normal and impaired fracture healing during the first 2 weeks after trauma (P-values were 0.0122, 0.0083, 0.0204, and