Elevated CRP and TNF-α levels are associated with blunted neural oscillations serving fluid intelligence.
Elevated CRP and TNF-α levels are associated with blunted neural oscillations serving fluid intelligence.
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CRP 和 TNF-α 水平升高与流体智力的神经振荡减弱有关。
DOI：
10.1016/j.bbi.2023.09.012
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Wilson,TonyW
中科院分区：
文献类型：
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作者：
Dietz,SarahM;Schantell,Mikki;Spooner,RachelK;Sandal,MeganE;Mansouri,Amirsalar;Arif,Yasra;Okelberry,HannahJ;John,JasonA;Glesinger,Ryan;May,PamelaE;Heinrichs-Graham,Elizabeth;Case,AdamJ;Zimmerman,MatthewC;Wilson,TonyW
炎症过程有助于保护身体免受细菌或病毒入侵等潜在威胁。然而，当这种炎症过程成为慢性参与时，突触损伤和神经元细胞死亡可能发生。特别是，持续高水平的c反应蛋白（CRP）和肿瘤坏死因子-α (TNF-α)与认知缺陷和几种精神疾病有关。高阶认知过程如流体智力（Gf）被认为特别容易受到持续炎症的影响。在此，我们研究了CRP和TNF-α升高与为Gf服务的神经振荡动力学之间的关系。方法70例20 ~ 66岁的成年人（平均45.17岁，SD= 16.29，女性21.4%）在脑磁图（MEG）中完成一项抽象推理任务，探测gff，并提供血液样本进行炎症标志物分析。MEG数据在时频域成像，在控制年龄、BMI和受教育程度的情况下，利用每个个体每次振荡反应的血浆CRP和TNF-α浓度进行全脑回归。结果scrp和TNF-α水平与区域特异性神经振荡反应显著相关。特别是，CRP浓度升高与右侧额下回和右侧小脑伽马活动的改变有关。相比之下，升高的TNF-α水平与左侧前扣带和左侧颞叶中部的α / β振荡以及左侧顶叶内沟的γ活动相对应。炎症标志物如CRP和TNF-α升高与Gf重要区域的异常神经振荡有关。将炎症标志物与区域神经振荡联系起来，可能有助于识别认知和精神疾病的机制。
IntroductionInflammatory processes help protect the body from potential threats such as bacterial or viral invasions. However, when such inflammatory processes become chronically engaged, synaptic impairments and neuronal cell death may occur. In particular, persistently high levels of C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) have been linked to deficits in cognition and several psychiatric disorders. Higher-order cognitive processes such as fluid intelligence (Gf) are thought to be particularly vulnerable to persistent inflammation. Herein, we investigated the relationship between elevated CRP and TNF-α and the neural oscillatory dynamics serving Gf.MethodsSeventy adults between the ages of 20–66 years (Mean= 45.17 years,SD= 16.29, 21.4% female) completed an abstract reasoning task that probes Gfduring magnetoencephalography (MEG) and provided a blood sample for inflammatory marker analysis. MEG data were imaged in the time–frequency domain, and whole-brain regressions were conducted using each individual’s plasma CRP and TNF-α concentrations per oscillatory response, controlling for age, BMI, and education.ResultsCRP and TNF-α levels were significantly associated with region-specific neural oscillatory responses. In particular, elevated CRP concentrations were associated with altered gamma activity in the right inferior frontal gyrus and right cerebellum. In contrast, elevated TNF-α levels scaled with alpha/beta oscillations in the left anterior cingulate and left middle temporal, and gamma activity in the left intraparietal sulcus.DiscussionElevated inflammatory markers such as CRP and TNF-α were associated with aberrant neural oscillations in regions important for Gf. Linking inflammatory markers with regional neural oscillations may hold promise in identifying mechanisms of cognitive and psychiatric disorders.