Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance
Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance
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DOI：
10.1021/acs.jmedchem.9b00370
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发表时间：
2019-09-12
影响因子：
7.3
通讯作者：
Huigens, Robert W., III
中科院分区：
文献类型：
--
作者：
Abouelhassan, Yasmeen;Garrison, Aaron T.;Huigens, Robert W., III
细菌利用多种机制，使它们能够在治疗感染期间获得或获得对抗生素疗法的抗性。此外，细菌形成生物膜，其是富集群体的表面附着群落，所述富集群体含有包裹在生物分子的保护性细胞外基质内的持留细胞，导致慢性和复发性耐药性感染。抗生素耐药性和耐受性是主要的全球性问题，需要创新的治疗策略来应对与病原菌相关的挑战。从历史上看，天然产品在将新疗法引入临床治疗危及生命的细菌感染方面发挥了关键作用。该观点提供了抗生素耐药性和耐受性的概述，并强调了来自各种研究计划的最新进展（化学，生物学，药物发现和开发），这些研究计划涉及发现受各种天然产物抗生素启发的新抗菌剂。
Bacteria utilize multiple mechanisms that enable them to gain or acquire resistance to antibiotic therapies during the treatment of infections. In addition, bacteria form biofilms which are surface-attached communities of enriched populations containing persister cells encased within a protective extracellular matrix of biomolecules, leading to chronic and recurring antibiotic-tolerant infections. Antibiotic resistance and tolerance are major global problems that require innovative therapeutic strategies to address the challenges associated with pathogenic bacteria. Historically, natural products have played a critical role in bringing new therapies to the clinic to treat life-threatening bacterial infections. This Perspective provides an overview of antibiotic resistance and tolerance and highlights recent advances (chemistry, biology, drug discovery, and development) from various research programs involved in the discovery of new antibacterial agents inspired by a diverse series of natural product antibiotics.