The internal and external responsiveness of Functional Assessment of Cancer Therapy-Prostate (FACT-P) and Short Form-12 Health Survey version 2 (SF-12 v2) in patients with prostate cancer
The internal and external responsiveness of Functional Assessment of Cancer Therapy-Prostate (FACT-P) and Short Form-12 Health Survey version 2 (SF-12 v2) in patients with prostate cancer
复制标题
DOI：
10.1007/s11136-016-1254-1
复制
发表时间：
2016-09-01
影响因子：
3.5
通讯作者：
Yiu, M. K.
中科院分区：
文献类型：
--
作者：
Choi, Edmond P. H.;Wong, Carlos K. H.;Yiu, M. K.
目的探讨癌症治疗功能评估-前列腺（FACT-P）和简明健康调查表（简表-12）的反应性方法在基线和6个月时使用SF-12 v2和FACT-1对168名前列腺癌受试者进行调查，P第4版。采用配对t检验和广义估计方程评价内反应性。结果FACT-P和SF-12 v2检测阳性变化的内反应性较好。FACT-P和SF-12 v2未检测到阴性变化。FACT-P和SF-12 v2在区分一般健康状况改善和一般健康状况恶化方面表现最佳。FACT-P在区分一般健康状况不变和一般健康状况恶化方面表现更好。SF-12 V2表现更好，在区分不变的一般健康和改善一般health.Conclusions积极变化检测这些措施应谨慎解释，因为他们可能过于敏感，以检测“噪音”，这是没有临床意义。FACT-P和SF-12 v2检测阴性变化的能力令人失望。FACT-P的社会幸福感的内部和外部反应性无法得到支持，这表明它不适合纵向监测前列腺癌患者的HRQOL的社会组成部分。研究报告建议，应同时使用一般性措施和针对具体疾病的措施，以相辅相成。
Purpose To examine the responsiveness of Functional Assessment of Cancer Therapy-Prostate (FACT-P) and Short Form-12 Health Survey version 2 (SF-12 v2) in prostate cancer patients because there is a lack of evidence to support their responsiveness in this patient population.Methods One hundred sixty-eight subjects with prostate cancer were surveyed at baseline and at 6 months using the SF-12 v2 and FACT-P version 4. Internal responsiveness was assessed using paired t test and generalized estimating equation. External responsiveness was evaluated using receiver operating characteristic curve analysis.Results The internal responsiveness of the FACT-P and SF-12 v2 to detect positive change was satisfactory. The FACT-P and SF-12 v2 could not detect negative change. The FACT-P and the SF-12 v2 performed the best in distinguishing between improved general health and worsened general health. The FACT-P performed better in distinguishing between unchanged general health and worsened general health. The SF-12 v2 performed better in distinguishing between unchanged general health and improved general health.Conclusions Positive change detected by these measures should be interpreted with caution as they might be too responsive to detect "noise," which is not clinically significant. The ability of the FACT-P and the SF-12 v2 to detect negative change was disappointing. The internal and external responsiveness of the social well-being of the FACT-P cannot be supported, suggesting that it is not suitable to longitudinally monitor the social component of HRQOL in prostate cancer patients. The study suggested that generic and disease-specific measures should be used together to complement each other.