The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach cancers.
The role of BRCA1 and BRCA2 mutations in prostate, pancreatic and stomach cancers.
复制标题
DOI：
10.1186/s13053-015-0038-x
复制
发表时间：
2015
影响因子：
1.7
通讯作者：
Rogers KM
中科院分区：
文献类型：
--
作者：
Cavanagh H;Rogers KM
乳腺癌易感基因1 （BRCA1）和乳腺癌易感基因2 （BRCA2）的种系突变与乳腺癌和卵巢癌的发展之间的关系已被广泛研究和认识。众所周知，这些基因在身体的多个部位起作用。研究随后发展到BRCA1/2与体内其他部位癌症的联系。本文综述了BRCA1/2种系基因突变与前列腺癌、胰腺癌和胃癌的关系。广泛的文献检索揭示了关于BRCA1/2基因突变与这些癌症之间关系的相互矛盾的发现。大多数研究表明，BRCA1/2突变与前列腺癌、胰腺癌和胃癌之间存在关联，但也有报道认为，这种相关性可能是由于BRCA1/2基因突变以外的因素，随着流行病学信息的进一步深入，其他关联可能会被揭示。这篇综述的结论是，随着对BRCA1/2基因突变机制的了解越来越多，它应该为未来有效应用筛查方案铺平道路。
The association of germline mutations in the breast cancer susceptibility gene 1 (BRCA1) and the breast cancer susceptibility gene 2 (BRCA2) with the development of breast and ovarian cancers have been widely researched and recognised. It is known that these genes function at multiple sites in the body. Research has subsequently evolved into the connection of BRCA1/2 with cancers at other sites within the body. This review examines the association of BRCA1/2 germline gene mutations with prostate, pancreatic and stomach cancers. An extensive literature search revealed conflicting findings regarding the association of BRCA1/2 gene mutations with these cancers. Most studies suggest that there is an association between BRCA1/2 mutations and carcinoma of the prostate, pancreas and stomach, but some reports propose that such a correlation may be due to factors other than possessing a mutated BRCA1/2 gene, and other associations may be revealed as further epidemiological information becomes available. The review concludes that as more knowledge arises about the mechanisms of BRCA1/2 gene mutations, it should pave the way for future screening programmes to be applied effectively.