Serum and follicular fluid irisin levels in women with polycystic ovaries undergoing ovarian stimulation: correlation with insulin resistance and lipoprotein lipid profiles
Serum and follicular fluid irisin levels in women with polycystic ovaries undergoing ovarian stimulation: correlation with insulin resistance and lipoprotein lipid profiles
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DOI：
10.1080/09513590.2019.1594761
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发表时间：
2019-04-11
影响因子：
2
通讯作者：
Baka, Stavroula
中科院分区：
文献类型：
--
作者：
Bousmpoula, Artemis;Benidis, Evangelos;Baka, Stavroula
鸢尾素是一种新的运动诱导的肌肉因子，与人体代谢的不同方面有关，可能与多囊卵巢综合征（PCOS）有关。本研究旨在探讨多囊卵巢综合征（PCOS）和接受卵巢控制刺激的正常女性血清和卵泡液（FF）鸢尾素水平，并将其与脂质和脂蛋白水平以及其他代谢参数联系起来。在体外受精（IVF）治疗下，对70名诊断为PCOS的女性和70名非PCOS对照组的血清和FF鸢尾素以及血脂和脂蛋白水平进行了评估。无论BMI如何，多囊卵巢综合征患者的卵母细胞数量、受精卵细胞数量和移植胚胎数量都显著增加，尽管两组之间成功怀孕的女性数量没有差异。FF鸢尾素水平与妊娠之间没有相关性。多囊卵巢综合征和超重妇女的血清和FF鸢尾素水平显著升高，并与BMI和血脂异常呈正相关。FF鸢尾素水平与血清鸢尾素水平呈正相关且低于血清鸢尾素水平。进一步的研究将有助于分析鸢尾素在雌性生殖中的作用，以及在人体代谢和多囊卵巢综合征的病理生理中的作用。
Irisin, a novel exercise-induced myokine, has been implicated in different aspects of human metabolism and could be connected to polycystic ovary syndrome (PCOS). This study aimed to investigate serum and follicular fluid (FF) irisin levels in PCOS and normal women undergoing controlled ovarian stimulation and correlate them to the lipid and lipoprotein levels as well as with other metabolic parameters. Serum and FF irisin, together with serum lipid and lipoprotein levels were assessed in 70 women with diagnosed PCOS and 70 non-PCOS controls, under in vitro fertilization (IVF) treatment. Regardless of BMI, PCOS women had a significantly increased number of oocytes retrieved, fertilized oocytes and transferred embryos, although the number of women achieving pregnancies did not differ between groups. No correlation between FF irisin levels and pregnancy could be established. Serum and FF irisin levels were significantly higher in PCOS and overweight women and were positively associated with BMI and dyslipidemia. FF irisin levels correlated positively to and were lower than serum irisin levels. Further research would be helpful to analyze irisin's role in female reproduction, if any, as well as in human metabolism and the pathophysiology of PCOS.