INTERLEUKIN-1 INCREASES NOREPINEPHRINE TURNOVER IN THE SPLEEN AND LUNG IN RATS
INTERLEUKIN-1 INCREASES NOREPINEPHRINE TURNOVER IN THE SPLEEN AND LUNG IN RATS
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DOI：
10.1016/s0006-291x(05)80923-4
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发表时间：
1990-12-31
影响因子：
3.1
通讯作者：
SAITO, M
中科院分区：
文献类型：
--
作者：
AKIYOSHI, M;SHIMIZU, Y;SAITO, M
为了阐明白细胞介素-1对交感神经活性的作用，在腹膜内注射重组人白细胞介素-1 β后，在大鼠中评估各种器官中的去甲肾上腺素周转。白细胞介素-1给药增加了脾、肺和下丘脑中的去甲肾上腺素周转率，但对心脏、肝脏、颌下腺、胸腺、胰腺、棕色脂肪组织和延髓无明显影响。在给予细菌内毒素后也发现去甲肾上腺素周转的类似变化。结论是白细胞介素-I激活脾和肺中特异性的交感神经。
To clarifiy effects of interleukin-1 on sympathetic nerve activity, norepinephrine turnover in various organs was assessed in rats after intraperitoneal injection of recombinant human interleukin-1.beta.. Interleukin-1 administration increased norepinephrine turnover in the spleen, lung and hypothalamus without appreciable effect in the heart, liver, submandibular gland, thymus, pancreas, brown adipose tissue and medulla oblongata. Similar changes in norepinephrine turnover were also found after the administration of bacterial endotoxin. It was concluded that interleukin-l activates the sympathetic nerves specifically in the spleen and lung.