Palladium-Catalyzed Stereoselective Intramolecular Heck Dearomative Silylation of Indoles
Palladium-Catalyzed Stereoselective Intramolecular Heck Dearomative Silylation of Indoles
复制标题
钯催化吲哚的立体选择性分子内 Heck 脱芳香硅烷化
DOI：
10.1002/adsc.202101183
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Chenjiang Liu
中科院分区：
文献类型：
--
作者：
Gang Wang;Mingzhu Wei;Tianxiang Liu;Weiwei Jin;Yonghong Zhang;Bin Wang;Yu Xia;Chenjiang Liu
A palladium‐catalyzed stereoselective intramolecular Heck dearomative of indoles with silyl termination has been developed. A type of tetracyclic indoline derivatives containing silicon were prepared, involvingN‐(2‐bromobenzoyl)indoles and silylboronates. This protocol not only led to a broad substrate scope in acceptable yields but also could be scaled up to gram quantities as well as further synthetic transformation.
