Quantitative informant- and self-reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4.
Quantitative informant- and self-reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4.
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主观认知下降的定量线人和自我报告预测了独立于年龄和APOEε4的认知无损害个体中淀粉样蛋白βPET的结果。
DOI：
10.1002/dad2.12127
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
ALFA Study
中科院分区：
文献类型：
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作者：
Sánchez-Benavides G;Salvadó G;Arenaza-Urquijo EM;Grau-Rivera O;Suárez-Calvet M;Milà-Alomà M;González-de-Echávarri JM;Minguillon C;Crous-Bou M;Niñerola-Baizán A;Perissinotti A;Gispert JD;Molinuevo JL;ALFA Study
β淀粉样蛋白（Aβ）病理学是阿尔茨海默病的早期标志。在此，我们评估了自我和知情者对认知功能下降的纵向报告在预测认知功能未受损的中年人Aβ正电子发射断层扫描（PET）结果方面的价值。来自ALFA+研究的共261名参与者在扫描前3年同时接受了[18F] flutemetetrainPET和主观认知下降问卷（SCD‐Q）。我们使用逻辑回归评估SCD‐Q评分（自我和被访者）预测Aβ PET目视读数的能力，并使用重复方差分析评估SCD‐Q评分的变化是否与Aβ状态相关。记忆力下降的自我感知（优势比[OR] = 1.2）和执行力下降的信息感知（OR = 1.6）增加了积极扫描的概率。扫描前3年的报告预测了Aβ PET结局。自我报告的执行能力下降的纵向增加预测女性中的Aβ（P = .003）。认知功能下降的主观报告有助于预测Aβ，并可能改善招募策略。
Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self‐ and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively unimpaired middle‐aged individuals. A total of 261 participants from the ALFA+ study underwent [18F]flutemetamol PET and Subjective Cognitive Decline Questionnaire (SCD‐Q) concurrently, and 3 years before scan. We used logistic regressions to evaluate the ability of SCD‐Q scores (self and informant) to predict Aβ PET visual read, and repeated analysis of variance to assess whether changes in SCD‐Q scores relate to Aβ status. Self‐perception of decline in memory (odds ratio [OR] = 1.2), and informant perception of executive decline (OR = 1.6), increased the probability of a positive scan. Informant reports 3 years before scanning predicted Aβ PET outcome. Longitudinal increase of self‐reported executive decline was predictive of Aβ in women (P = .003). Subjective reports of cognitive decline are useful to predict Aβ and may improve recruitment strategies.