Medicated Manuka honey in conservative management of exomphalos major
Medicated Manuka honey in conservative management of exomphalos major
复制标题
药用麦卢卡蜂蜜在保守治疗大拇外翻中的应用
DOI：
10.1007/s00383-014-3490-1
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
D. Parikh
中科院分区：
文献类型：
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作者：
C. Nicoara;Michael N. Singh;I. Jester;B. Reda;D. Parikh
目的评价麦卢卡蜂蜜软膏和敷料在保守治疗大外凸（EM）中的疗效。方法回顾性分析5例采用麦卢卡蜂蜜软膏和敷料非手术治疗的EM患者，评估其完成上皮化时间、完全喂养时间、住院时间、不良反应、并发症和预后。结果EM囊的皮肤上皮化平均时间为63天（48 ~ 119天）。到完全肠内喂养的中位时间为13天（3-29）。中位住院时间为66天（21-121天）。没有发现与麦卢卡蜂蜜有关的不良反应。3例患者肺部发育不全，需要长期住院治疗；其中一人在实现完全上皮化后死于呼吸道并发症。随访时间中位数为16个月（6-22）。2例患者不需要腹疝修补术。1例患者16个月时腹疝修补，术后美观良好。剩下的病人正在等待修复。结论首次报道了麦卢卡蜂蜜软膏和浸渍敷料在EM保守治疗中的应用，该治疗方法安全有效，促进创面愈合，效果良好。
PurposeThe aim of this study was to assess the effectiveness of Manuka honey ointment and dressings in the conservative management of exomphalos major (EM).MethodsA retrospective review of five patients with EM who underwent non-operative management with Manuka honey ointments and dressings was carried out to assess the time to complete epithelialisation, time to full feeds, hospital stay, adverse effects, complications and outcome.ResultsThe skin epithelialisation over the EM sac was achieved in a median of 63 days (48–119). The median time to full enteral feed was 13 days (3–29). The median hospital stay was 66 days (21–121). No adverse effects were noted related to Manuka honey. Three patients had pulmonary hypoplasia requiring prolonged hospitalization; one of those died with respiratory complications at home after achieving complete epithelialisation. The follow-up was a median 16 months (6–22). Two patients did not require repair of the ventral hernia. One patient had ventral hernia repair at 16 months with excellent cosmesis. The remaining patient is awaiting repair.ConclusionThis is the first description of the use of medicated Manuka honey ointment and impregnated dressings in the conservative management of EM. This treatment is safe, efficacious and promotes wound healing with favorable outcome.