The value of BAL fluid LDH level in differentiating benign from malignant solitary pulmonary nodules
The value of BAL fluid LDH level in differentiating benign from malignant solitary pulmonary nodules
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DOI：
10.1007/s00432-007-0311-0
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发表时间：
2008-04-01
影响因子：
3.6
通讯作者：
Emad, Vahid
中科院分区：
文献类型：
--
作者：
Emad, Ali;Emad, Vahid
目的血清乳酸脱氢酶（LDH）浓度是反映组织损伤的指标.在某些情况下可局部分泌。本研究旨在探讨支气管肺泡灌洗液（BALF）中乳酸脱氢酶（LDH）水平在孤立性肺结节（SPN）良恶性鉴别诊断中的价值及其与血清LDH水平的关系。其中包括59例SPN患者。他们接受了支气管镜检查和支气管肺泡灌洗（BAL）。结果恶性SPN患者BALF中LDH水平明显升高，BALF中LDH水平明显升高。恶性SPN患者BALF LDH水平（342.23 ± 89.98）显著高于良性SPN患者（17.62 ± 7.90）（P < 0.001）。结论恶性SPN患者BALF中LDH水平升高，而良性SPN患者BALF中LDH水平升高不明显。这一因素有助于鉴别良恶性SPN。
Purpose Serum lactate dehydrogenase (LDH) concentration is an indicator of tissue injury. It may be locally secreted in some conditions. This study was performed in order to investigate the value of LDH levels in bronchoalveolar lavage fluid (BALF) in the differentiation of a bening, from a malignant solitary pulmonary nodules (SPN) and to assess its relationship with serum LDH levels.Methods The study was a prospective clinical study. It included 59 patients with a SPN. They underwent bronchoscopy with bronchoalveolar lavage (BAL). Both total serum and BAL LDH levels were measured.Results BALF LDH level was increased in all patients with malignant SPN. The mean BALF LDH level was significantly higher in patients with malignant SPN (342.23 +/- 89.98) as compared to the benign ones (17.62 +/- 7.90) (P < 0.001). There was no correlation between BALF LDH and serum LDH level in patients with SPNs (P = 0.595).Conclusion BALF LDH levels are increased in patients with malignant SPN, but had no significant rise in benign SPN. This factor is useful in differentiating the benign SPNs from malignant SPNs.