Comparative effects of bepridil, diltiazem, nifedipine and verapamil on haemodynamic parameters and myocardial oxygen consumption in anaesthetized dogs.
Comparative effects of bepridil, diltiazem, nifedipine and verapamil on haemodynamic parameters and myocardial oxygen consumption in anaesthetized dogs.
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贝普地尔、地尔硫卓、硝苯地平和维拉帕米对麻醉犬血流动力学参数和心肌耗氧量的比较影响。
DOI：
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发表时间：
1986
影响因子：
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通讯作者：
J. Lamar
中科院分区：
文献类型：
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作者：
M. Beaughard;M. Michelin;J. Tisne;J. Lamar
4种钙拮抗剂苄普地尔（1.25 - 5 mg/kg i. v.），地尔硫卓（0.1 - 0.3 mg/kg i. v.），硝苯地平（0.01至0.03 mg/kg i. v.）和维拉帕米（0.1至0.3 mg/kg i. v.）在麻醉开胸犬中进行比较。测定窦冠状动脉血流量（SCBF）、冠状动脉总阻力（TCVR）、主动脉血压、心率、左室dP/dt max、右室收缩幅度、双乘积、心肌耗氧量（MVO 2）、动脉血气（pO 2）、冠状静脉血气（pCO 2）和pH值。考虑到相对剂量大小，硝苯地平和维拉帕米的作用最大。这2种物质对全身血管舒张的影响也最大，表现为低血压。这4种物质对心肌有直接的负性变时作用，这种作用被反射性交感神经刺激和继发于血压下降的迷走神经张力降低所掩盖。最明显的负性变时作用依次为地尔硫卓、维拉帕米和苄普地尔。硝苯地平和维拉帕米产生最大的负性肌力作用，而地尔硫卓对该参数的影响很小。这4种物质的血液动力学作用的直接结果是改善心肌的氧合。硝苯地平和维拉帕米对PvO 2的影响最持久。这些发现不仅证明了4种钙拮抗剂的异质性作用，而且还证明了实验条件对这些物质所获得的效果的影响。
The haemodynamic effects of 4 calcium antagonists, bepridil (1.25 to 5 mg/kg i.v.), diltiazem (0.1 to 0.3 mg/kg i.v.), nifedipine (0.01 to 0.03 mg/kg i.v.) and verapamil (0.1 to 0.3 mg/kg i.v.) were compared in anaesthetized open-chest dogs. The following parameters were measured: sinusal coronary blood flow (SCBF), total coronary vascular resistance (TCVR), aortic blood pressure, heart rate, left dP/dt max, amplitude of right ventricular contraction, double product, myocardial oxygen consumption (MVO2) and arterial and coronary venous blood gases (pO2 and pCO2) and pH. All 4 substances increased SCBF and decreased TCVR. The greatest effects, taking into account relative dose size, were obtained with nifedipine and verapamil. These 2 substances also had the greatest effect on systemic vasodilatation, as reflected by hypotension. The 4 substances had a direct negative chronotropic effect on the myocardium, an effect which was masked by reflex sympathetic stimulation and decreased vagal tone secondary to a drop in blood pressure. The most marked negative chronotropic effects were seen with diltiazem, verapamil and bepridil in that order. Nifedipine and verapamil produced the greatest negative inotropic effects, whereas diltiazem had very little effect on this parameter. The direct consequence of these haemodynamic effects of the 4 substances was to improve oxygenation of the myocardium. The most durable effect on PvO2 was seen with nifedipine and verapamil. The findings demonstrate not only the heterogeneous action of the 4 calcium antagonists, but also the influence of the experimental conditions on the effects obtained with these substances.