Are some feasibility studies more feasible than others? A review of the outcomes of feasibility studies on the ISRCTN registry.
Are some feasibility studies more feasible than others? A review of the outcomes of feasibility studies on the ISRCTN registry.
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DOI：
10.1186/s40814-021-00931-y
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发表时间：
2021-11-08
影响因子：
1.7
通讯作者：
Ziebland S
中科院分区：
文献类型：
--
作者：
Morgan B;Hejdenberg J;Kuleszewicz K;Armstrong D;Ziebland S
可行性研究通常在进行随机对照试验（RCT）之前进行，但很少有已发表的证据表明可行性研究有多有用，特别是在增加或减少研究浪费方面。本研究试图根据主题领域和/或研究环境，检查有多少可行性研究证明了完整试验是可行的，以及一些可行性研究本身是否可能是可行的。在国际标准随机对照试验编号（ISRCTN）登记处进行关键词检索，以识别在英国进行的所有已完成的可行性研究。在1933年确定的625份记录被审查之前，很明显继续下去是徒劳的。在确定的329项可行性研究中，160项（49%）具有已知结局，133项（83%）试验被认为是可行的，只有27项（17%）报告为不可行。因此，研究太少，无法按主题和/或背景对不可行研究的差异进行预期比较。有太少的研究报告为不可行的得出任何有用的结论是否主题和/或设置有影响。然而，高可行性率（83%）可能表明不可行的研究受到出版偏倚的影响，或者许多可行性研究是多余的，可能会增加研究途径的浪费。
Feasibility studies are often conducted before committing to a randomised controlled trial (RCT), yet there is little published evidence to inform how useful feasibility studies are, especially in terms of adding or reducing waste in research. This study attempted to examine how many feasibility studies demonstrated that the full trial was feasible and whether some feasibility studies were inherently likely to be feasible or not feasible, based on the topic area and/or research setting. Keyword searches were conducted on the International Standard Randomised Controlled Trials Number (ISRCTN) registry to identify all completed feasibility studies which had been conducted in the UK. A total of 625 records from the 1933 identified were reviewed before it became evident that it would be futile to continue. Of 329 feasibility studies identified, 160 had a known outcome (49%), 133 (83%) trials were deemed to be feasible and only 27 (17%) were reported to be non-feasible. There were therefore too few studies to allow the intended comparison of differences in non-feasible studies by topic and/or setting. There were too few studies reported as non-feasible to draw any useful conclusions on whether topic and/or setting had an effect. However, the high feasibility rate (83%) may suggest that non-feasible studies are subject to publication bias or that many feasible studies are redundant and may be adding waste to the research pathway.
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影响因子：
168.9
作者：
DeVito, Nicholas J.;Bacon, Seb;Goldacre, Ben
通讯作者：
Goldacre, Ben
DOI：
10.1136/bmj.k3218
发表时间：
2018-09-12
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Goldacre B;DeVito NJ;Heneghan C;Irving F;Bacon S;Fleminger J;Curtis H
通讯作者：
Curtis H
影响因子：
158.5
作者：
Anderson, Monique L.;Chiswell, Karen;Califf, Robert M.
通讯作者：
Califf, Robert M.
影响因子：
3.7
作者：
Morgan, Ben;Hejdenberg, Jennie;Armstrong, David
通讯作者：
Armstrong, David
影响因子：
9.6
作者：
Fairhurst, K.;Blazeby, J. M.;Avery, K. N. L.
通讯作者：
Avery, K. N. L.