OBSERVATIONS ON THE THERMOREGULATORY EFFECTS OF PREOPTIC WARMING IN RATS
OBSERVATIONS ON THE THERMOREGULATORY EFFECTS OF PREOPTIC WARMING IN RATS
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DOI：
10.1016/0031-9384(79)90166-5
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发表时间：
1979-01-01
影响因子：
2.9
通讯作者：
LAUDENSLAGER, ML
中科院分区：
文献类型：
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作者：
CARLISLE, HJ;LAUDENSLAGER, ML
实验升温的视前-前下丘脑区被用来评估行为和自主的温度调节热损失的反应。下丘脑变暖与减少行为的热量摄入和降低核心和外周温度的大鼠在寒冷的环境中工作的辐射热奖励。外界热反应的基线速率由环境温度决定，但视前升温过程中核心或外周温度的变化幅度则不确定。行为反应补偿环境温度的变化，使阈值下丘脑温度高于热损失被激活的视前区变暖不改变环境温度的变化。下丘脑升温过程中的热量损失是自主神经和行为体温调节反应的函数，因为在视前升温过程中，身体热含量的减少不能单独由行为热量摄入的减少来解释。当没有行为选择时，引发尾部血管舒张的下丘脑温度阈值随着环境温度的升高而系统性降低。在大鼠中，行为和自主体温调节反应合作，以确定的热量损失的幅度，这是成比例的视前变暖的幅度。
Experimental warming of the preoptic-anterior hypothalamic area was used to evaluate behavioral and autonomic thermoregulatory heat loss responses. Hypothalamic warming was associated with reduced behavioral heat intake and decreased core and peripheral temperatures in rats working for radiant heat reward in a cold environment. Baseline rates of responding for external heat were determined by ambient temperature, but the magnitude of changes in core or peripheral temperatures during preoptic warming were not. Behavioral responses compensated for variations in ambient temperature so that the threshold hypothalamic temperature above which heat loss was activated by preoptic warming was not altered by changing ambient temperatures. Heat loss during hypothalamic warming was a function of autonomic and behavioral thermoregulatory responses because the decrease in body heat content during preoptic warming could not be accounted for by the decreased behavioral heat intake alone. The threshold hypothalamic temperature for elicitation of tail vasodilation decreased systematically as ambient temperature increased when no behavioral option was available. In the rat, behavioral and autonomic thermoregulatory responses cooperate to determine the magnitude of heat loss which is proportional to the magnitude of preoptic warming.