The role of mast cells and their mediators in reproduction, pregnancy and labour
The role of mast cells and their mediators in reproduction, pregnancy and labour
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DOI：
10.1093/humupd/dmq053
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发表时间：
2011-05-01
影响因子：
13.3
通讯作者：
Nelson, S. M.
中科院分区：
文献类型：
--
作者：
Menzies, F. M.;Shepherd, M. C.;Nelson, S. M.
背景技术背景：肥大细胞（Mast cell，MC）是过敏反应的经典介导者，但其在先天性和适应性免疫应答中的重要性正日益被认识。在此，本MC文献进行了总结，特别侧重于研究MC在子宫内膜和子宫肌层，其参与生育，植入，妊娠和labour.METHODS：MC生物学的最新进展进行了系统检索PubMed，Medline和谷歌学术2000年至2009年11月。为了具体研究MC在生育和妊娠中的作用，我们对PubMed、Medline和Google Scholar数据库中引用的英文文献进行了系统综述，但将检索期从1980年延长至2010年1月。MC可以对免疫球蛋白E非依赖性先天免疫刺激做出反应，并且存在于子宫内膜内，在月经前发生介质的激活和释放，并与子宫内膜异位症有关。关于妊娠，MC在胚泡植入期间是多余的，尽管其介质可以诱导子宫肌层收缩性，但早产与过敏症没有流行病学联系，表明其作用不重要或具有强大的调节作用。在男性中，MCs存在于睾丸中，并在寡精症和无精症中增加，MC介质直接抑制精子活力，在一个潜在的可逆marty.Conclusions：MCs是普遍存在于女性和男性生殖道。然而，MCs是否是成功妊娠的绝对必要条件，或者是生殖病理学的基础，从而成为治疗靶点，仍有待确定。
BACKGROUND: Mast cells (MCs) are the classical mediators of allergy, however, their importance in the development of innate and adaptive immune responses is increasingly being recognized. Herein, the present MC literature is summarized, with particular focus on studies of MCs in the endometrium and myometrium, and their involvement in fertility, implantation, pregnancy and labour.METHODS: Recent developments in MC biology were identified by systematic searches of PubMed, Medline and Google Scholar from 2000 to November 2009. To specifically examine the role of MCs in fertility and pregnancy, we then performed a systematic review of English literature cited in the PubMed, Medline and Google Scholar databases, but extended the search period, from 1980 to January 2010RESULTS: MCs can respond to immunoglobulin E-independent innate immune stimuli and are present within the endometrium, with activation and release of mediators occurring prior to menstruation and in association with endometriosis. With respect to pregnancy, MCs are redundant during blastocyst implantation and although their mediators can induce myometrial contractility, there is no epidemiological link of preterm birth with allergy, suggesting a non-essential role or robust regulation. In males, MCs are present in the testes and are increased in oligo- and azoospermia, with MC mediators directly suppressing sperm motility in a potentially reversible manner.CONCLUSIONS: MCs are prevalent in the female and male reproductive tract. However, whether MCs are absolutely required for a successful pregnancy or are fundamental to reproductive pathology, and thereby a therapeutic target, remains to be determined.