Impaired judgments of sadness but not happiness following bilateral amygdala damage
Impaired judgments of sadness but not happiness following bilateral amygdala damage
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DOI：
10.1162/089892904322926782
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发表时间：
2004-04-01
影响因子：
3.2
通讯作者：
Tranel, D
中科院分区：
文献类型：
--
作者：
Adolphs, R;Tranel, D
虽然杏仁核在处理恐惧的面部表情中的作用已经得到了很好的证实，但它在处理其他情绪中的作用还不清楚。特别是，杏仁核参与处理快乐和悲伤的表达的证据仍然存在争议。为了澄清这个问题，我们构建了一系列变形刺激，其情绪表达从非常微弱逐渐变化到更明显。对27名单侧杏仁核损伤和5名双侧杏仁核完全损伤的受试者分别显示悲伤和快乐的五种变体以及中性面孔，并将其数据与12名脑损伤和26名正常对照者的数据进行比较。受试者被要求评价强度和标记刺激。单侧杏仁核损伤的受试者表现非常接近对照组。相比之下，双侧杏仁核受损的受试者在评定悲伤面孔时表现出特定的障碍，但在评定快乐面孔时表现正常。此外，右侧单侧杏仁核损伤的受试者比左侧单侧杏仁核损伤的受试者表现更差。研究结果表明，杏仁核的多重负面情绪，包括恐惧和悲伤。
Although the amygdala's role in processing facial expressions of fear has been well established, its role in the processing of other emotions is unclear. In particular, evidence for the amygdala's involvement in processing expressions of happiness and sadness remains controversial. To clarify this issue, we constructed a series of morphed stimuli whose emotional expression varied gradually from very faint to more pronounced. five morphs each of sadness and happiness, as well as neutral faces, were shown to 27 subjects with unilateral amygdala damage and 5 with complete bilateral amygdala damage, whose data were compared to those from 12 brain-damaged and 26 normal controls. Subjects were asked to rate the intensity and to label the stimuli. Subjects with unilateral amygdala damage performed very comparably to controls. By contrast, subjects with bilateral amygdala damage showed a specific impairment in rating sad faces, but performed normally in rating happy faces. Furthermore, subjects with right unilateral amygdala damage performed somewhat worse than subjects with left unilateral amygdala damage. The findings suggest that the amygdala's multiple negatively valenced emotions, including fear and sadness.