Electrosynthesis of amino acids from biomass-derived α-hydroxyl acids
Electrosynthesis of amino acids from biomass-derived α-hydroxyl acids
复制标题
从生物质衍生的α-羟基酸电合成氨基酸
DOI：
10.1039/d2gc01779b
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发表时间：
2022
期刊：
影响因子：
9.8
通讯作者：
Sun, Yujie
中科院分区：
文献类型：
--
作者：
Yan, Kaili;Huddleston, Morgan L.;Gerdes, Brett A.;Sun, Yujie
生物质衍生中间体化合物的电化学转化为高价值产品已成为生物炼制领域中一种有前途的方法。生物质升级可利用非化石碳源生产化学品，并将电力资本化，作为一种绿色能源投入。氨基酸作为生物质升级的产物，受到的关注相对较少。制药和食品工业将受益于一种替代的氨基酸生产策略，这种策略不依赖于低效的发酵过程。使用可再生的生物质资源作为起始材料，使这一拟议的战略更可取。在此，我们报道了一种电化学方法，用于生物质衍生的α-羟基酸选择性氧化为α-酮酸，然后通过电化学还原胺化得到最终产物氨基酸。这种策略利用了阳极和阴极的反应，并在环境条件下以高能效生产氨基酸。流动电解槽也成功地用于α-羟基酸转化为氨基酸，突出了其大规模应用的巨大潜力。
Electrochemical conversion of biomass-derived intermediate compounds to high-value products has emerged as a promising approach in the field of biorefinery. Biomass upgrading allows for the production of chemicals from non-fossil-based carbon sources and capitalization on electricity as a green energy input. Amino acids, as products of biomass upgrading, have received relatively little attention. Pharmaceutical and food industries will benefit from an alternative strategy for the production of amino acids that does not rely on inefficient fermentation processes. The use of renewable biomass resources as starting materials makes this proposed strategy more desirable. Herein, we report an electrochemical approach for the selective oxidation of biomass-derived α-hydroxyl acids to α-keto acids, followed by electrochemical reductive amination to yield amino acids as the final products. Such a strategy takes advantage of both reactions at the anode and cathode and produces amino acids under ambient conditions with high energy efficiency. A flow electrolyzer was also successfully employed for the conversion of α-hydroxyl acids to amino acids, highlighting its great potential for large-scale application.