Herpetic eye disease: immunopathogenesis andtherapeutic measures
Herpetic eye disease: immunopathogenesis andtherapeutic measures
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DOI：
10.1017/s1462399404007604
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发表时间：
2004-03-30
影响因子：
6.2
通讯作者：
Rouse, Barry T.
中科院分区：
文献类型：
--
作者：
Deshpande, Shilpa;Banerjee, Kaustuv;Rouse, Barry T.
疱疹性眼病：单纯疱疹病毒（HSV）感染角膜可导致一种称为疱疹性角膜基质炎（HSK）的慢性疾病。这种疾病是西方世界传染性失明的主要原因之一。免疫介导的细胞损伤可能是HSK的发病机制之一。小鼠模型在进一步建立HSK作为免疫病理学疾病中是关键的。本文回顾了对人类和小鼠模型中HSK的了解，重点是未来可能的治疗策略来对抗这种致盲免疫炎症疾病。
Herpetic eye disease: immunopathogenesis andtherapeutic measures Infection of the cornea with herpes simplex virus (HSV) can result in a chronic disease called herpetic stromal keratitis (HSK). The disease represents one of the leading causes of infectious blindness in the Western world. Immune-mediated cellular damage is suspected in the pathogenesis of human HSK. The murine model has been pivotal in further establishing HSK as an immunopathological disease. This article reviews understanding of HSK, both in humans and in the mouse model, with an emphasis on possible future therapeutic strategies to counteract this blinding immunoinflammatory disease.