Stroke volume and cardiac output in normotensive children and adults. Assessment of relations with body size and impact of overweight.
Stroke volume and cardiac output in normotensive children and adults. Assessment of relations with body size and impact of overweight.
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DOI：
10.1161/01.cir.95.7.1837
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发表时间：
1997-04
期刊：
影响因子：
37.8
通讯作者：
G. Simone;R. B. Devereux;S. Daniels;G. Mureddu;M. Roman;T. Kimball;R. Greco;S. Witt;F. Contaldo
中科院分区：
文献类型：
--
作者：
G. Simone;R. B. Devereux;S. Daniels;G. Mureddu;M. Roman;T. Kimball;R. Greco;S. Witt;F. Contaldo
器官和身体大小之间的关系不是线性的，而是遵循异速生长（生长）关系，其特征在于它们的幂（指数）。方法和结果在970名正常血压个体（1天至85岁; 426名< 18岁; 204名超重至肥胖; 426名女性）中，M型超声心动图测量的每搏输出量（SV）与身高、体重、体表面积（BSA）和理想BSA（根据给定身高的理想体重推导出）相关。在正常体重的儿童、成人和整个人群中，SV与BSA（功效= 0.82至1.19）、体重（功效= 0.57至0.71）和身高（功效= 1.45至2.04）呈异速生长关系（均P <0.0001）。在整个人群中，心输出量与身体大小测量值的关系比SV的异速生长能力低（体重为0.41，BSA为0.62，身高为1.16）。在超重成人中，观察到的SV比理想BSA的预测值高17%，这一差异近似于身高SV与年龄特异性异速生长能力的归一化。同样，观察到的心输出量比理想BSA的预测值高19%，通过使用心输出量/身高与年龄特异性异速生长幂而不是BSA与第一幂的异速生长幂准确检测到差异。结论：当需要消除肥胖的影响时，BSA的SV和心输出量指标是相关的，因为这些指标掩盖了肥胖的影响。为了检测肥胖对左心室泵功能的影响，应将SV和心输出量标准化为理想BSA或身高与其年龄特异性异速生长功率。
BACKGROUND Relations between organs and body size are not linear but rather follow allometric (growth) relations characterized by their powers (exponents). METHODS AND RESULTS Stroke volume (SV) by M-mode echocardiography was related to height, weight, body surface area (BSA), and ideal BSA (derived from ideal body weight for given height) in 970 normotensive individuals (1 day to 85 years old; 426 < 18 years old; 204 overweight to obese; 426 female). In normal-weight children, adults, and the entire population, SV was related by allometric relations to BSA (power = 0.82 to 1.19), body weight (power = 0.57 to 0.71), and height (power = 1.45 to 2.04) (all P < .0001). Relations of cardiac output to measures of body size had lower allometric powers than those for SV in the entire population (0.41 for body weight, 0.62 for BSA, and 1.16 for height). In overweight adults, observed SVs were 17% greater than predicted for ideal BSA, a difference that was approximated by normalization of SV for height to age-specific allometric powers. Similarly, observed cardiac output was 19% greater than predicted for ideal BSA, a difference that was accurately detected by use of cardiac output/height to age-specific allometric powers but not of BSA to the first power. CONCLUSIONS Indices of SV and cardiac output for BSA are pertinent when the effect of obesity needs to be removed, because these indices obscure the impact of obesity. To detect the effect of obesity on LV pump function, normalization of SV and cardiac output for ideal BSA or for height to its age-specific allometric power should be practiced.