Efficacy of glycolic acid peels in the treatment of melasma.
Efficacy of glycolic acid peels in the treatment of melasma.
复制标题
乙醇酸换肤治疗黄褐斑的功效。
作者：
M. Hurley;Ian L. Guevara;R. Gonzales;A. Pandya
背景
黑斑病是一种获得性的色素沉着过度，用色素减退剂治疗往往无效。
目的
评估4%氢醌霜与4%氢醌霜联合乙醇酸皮治疗黄褐斑的疗效。
方法
21名患有双侧表皮和混合性黄褐斑的西班牙裔妇女参加了一项为期8周的裂面前瞻性试验。患者每2周仅在一侧面部进行20%至30%的乙醇酸剥离，此外每天早上每天两次全脸应用4%氢醌霜和防晒因子25 UV-B防晒霜。使用mexameter和黄褐斑面积和严重程度指数客观地测量色素沉着，并使用线性模拟量表和医生和患者的整体评价主观地测量色素沉着。
结果
与基线相比，氢醌单独治疗和氢醌与乙醇酸联合治疗在减少皮肤色素沉着方面具有显著效果（P<0.001）。然而，与单独使用氢醌相比，使用联合治疗没有发现显著差异（P = 0.75）。
结论
使用4%对苯二酚和每日使用防晒霜可有效治疗黄褐斑;然而，添加4片乙醇酸果皮并不能增强单独使用对苯二酚治疗的色素减退效果。
BACKGROUND
Melasma is an acquired hypermelanosis that is often recalcitrant to treatment with hypopigmenting agents.
OBJECTIVE
To assess the efficacy of 4% hydroquinone cream vs 4% hydroquinone cream combined with glycolic acid peels as treatment for melasma.
METHODS
Twenty-one Hispanic women with bilateral epidermal and mixed melasma were enrolled in a split-faced prospective trial lasting 8 weeks. Patients underwent 20% to 30% glycolic acid peels every 2 weeks to one side of the face only in addition to twice-daily full-face application of 4% hydroquinone cream and sun protective factor 25 UV-B sunscreen each morning. Pigmentation was measured objectively using a mexameter and the Melasma Area and Severity Index and subjectively using a linear analog scale and physician and patient global evaluation.
RESULTS
Hydroquinone treatment alone and treatment with the combination of hydroquinone and glycolic acid had a significant effect in reducing skin pigmentation compared with baseline (P<.001). However, no significant difference was found using combination therapy compared with hydroquinone alone (P =.75).
CONCLUSIONS
Use of 4% hydroquinone and a daily sunscreen is effective in the treatment of melasma; however, the addition of 4 glycolic acid peels did not enhance the hypopigmenting effect of hydroquinone treatment alone.