Hematological profile of sickle cell disease from South Gujarat, India.
Hematological profile of sickle cell disease from South Gujarat, India.
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DOI：
10.4081/hr.2012.e8
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发表时间：
2012-05-10
影响因子：
0.9
通讯作者：
Shah VB
中科院分区：
文献类型：
--
作者：
Rao SS;Goyal JP;Raghunath SV;Shah VB
本研究的目的是确定印度南古吉拉特邦苏拉特镰状细胞病 (SCD) 的血液学特征。这项前瞻性横断面研究于 2009 年 7 月至 2010 年 12 月在印度苏拉特政府医学院病理学系儿科和镰状细胞贫血实验室进行。这项研究中的患者在很长一段时间内处于稳定状态，没有任何与 SCD 或其他可能影响血液学参数的疾病相关的症状。所有患者均采集乙二胺四乙酸静脉血并测定血液学指标。研究了总共 33 名纯合受试者的镰状细胞性贫血血液学参数。中度至重度贫血、平均细胞体积低和胎儿血红蛋白高是 SCD 儿童血液学特征的主要特征。
The aim of this study was to determine hematological profile of sickle cell disease (SCD) from Surat, South Gujarat, India. This prospective cross-sectional study was conducted in the Department of Pediatrics and Sickle Cell Anemia Laboratory, Faculty of Pathology, Government Medical College, Surat, India, between July 2009 and December 2010. Patients included in this study were in their steady state for a long period of time without any symptoms related to SCD or other diseases which could affect the hematological parameters. Venous blood of all patients was collected in ethylenediaminetetraacetic acid and hematological indices were measured. Thirty-three subjects homozygous in all were studied for their hematological parameters for sickle cell anemia. Moderate to severe anemia, low mean cell volume and high foetal hemoglobin dominate the hematological profile of SCD children.