Validation of the Friedewald formula for the determination of low-density lipoprotein cholesterol compared with β-quantification in a large population
Validation of the Friedewald formula for the determination of low-density lipoprotein cholesterol compared with β-quantification in a large population
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DOI：
10.1016/j.clinbiochem.2004.03.008
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发表时间：
2004-09-01
影响因子：
2.8
通讯作者：
Couture, P
中科院分区：
文献类型：
--
作者：
Tremblay, AJ;Morrissette, H;Couture, P
来自9477名受试者的脂蛋白数据，涵盖了广泛的血浆总胆固醇水平，用于检验Friedewald公式的有效性，该公式使用高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TG）浓度来估计低密度脂蛋白胆固醇（LDL-C）的血浆浓度。用弗里德瓦尔德公式计算LDL-C值，并与制备超离心法计算LDL-C值进行比较。我们发现与Friedewald公式相关的偏差与血浆LDL-C水平无关，即使是血浆LDL-C值也小于-4.0%
Lipoprotein data from 9477 subjects, covering a wide range of total plasma cholesterol levels, were used to examine the validity of the Friedewald formula for estimating plasma concentrations of low-density lipoprotein cholesterol (LDL-C) using high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) concentrations. Values of LDL-C obtained from the Friedewald formula were compared with values of LDL-C derived from preparative ultracentrifugation used as a reference method. We found that the bias associated with the Friedewald formula was not related to plasma LDL-C levels and was smaller than -4.0% even for plasma LDL-C values