Magnetoviscous effect in ferrofluids diluted with sheep blood
Magnetoviscous effect in ferrofluids diluted with sheep blood
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DOI：
10.1016/j.jmmm.2017.07.029
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发表时间：
2017-11-15
影响因子：
2.7
通讯作者：
Odenbach, S.
中科院分区：
文献类型：
--
作者：
Nowak, J.;Borin, D.;Odenbach, S.
磁性纳米颗粒悬浮在合适的载体液体中，被称为铁磁流体，是当前生物医学领域研究的重点。这些液体可以潜在地用于治疗癌症，通过耦合化疗药物并在外部磁场的帮助下或通过人工局部诱导加热将其积聚在患病区域。这些应用依赖于外部磁场的帮助，众所周知，外部磁场会极大地影响铁磁流体的物理行为。本研究探讨了生物相容性铁磁流体在接近生物医学应用的流动情况下粘度的变化。为此目的，血液作为稀释剂和细毛细血管被利用。由于所发现的强磁粘性效应，我们假设在外加磁场的作用下，材料的微观结构会发生很大的变化，并利用微观装置对其进行了研究和量化。结果表明，在较强磁场下，结构尺寸增大，结构形成速度加快。此外，随着外加磁场持续时间的增加，结构的尺寸也随之增大。观察到的结构形成过程是可逆的。(C) 2017 Elsevier B.V.版权所有
Suspensions of magnetic nanoparticles in suitable carrier liquids, denoted as ferrofluids, are in the focus of current research in the biomedical area. Those fluids can be potentially used for the treatment of cancer by coupling chemotherapeutic agents and accumulating them in the diseased region with the help of external magnetic fields or by artificially local induced heating. Those applications rely on the help of external magnetic fields, which are well known to drastically influence the physical behaviour of ferrofluids. This study investigates the changing viscosity of a biocompatible ferrofluid in a flow situation close to the situation found in a biomedical application. For this purpose blood as diluting agent and thin capillaries have been utilised. The strong magnetoviscous effects found lead to the assumption of quite big changes of the microstructure due to the external magnetic fields, which was investigated and quantified using a microscopic setup. In the result an increases of the structure size as well as faster structure formation in the stronger magnetic fields were observed. Moreover, with increasing duration of the applied magnetic field the size of the structures increases too. The observed process of the structure formation is reversible. (C) 2017 Elsevier B.V. All rights reserved.