AN EXPERIMENTAL STUDY.*
AN EXPERIMENTAL STUDY.*
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实验研究。*
DOI：
10.1097/00006982-199212031-00008
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
Gerhard G Grabenbauer
中科院分区：
文献类型：
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作者：
Stefan Schultze;F. Wehrhan;Kerstin Amann;Martin Radespiel;Franz Rödel;Gerhard G Grabenbauer
在动物身上复制与人类动脉病变相似的病变的方法很多，这表明对动脉硬化的病因存在着不同的看法。为了进一步阐明这种观点，作者毫不犹豫地指出了实验性病变与动脉硬化类型的相似性。因此，人们很快就被人类和动物动脉中各种各样的病变所震惊，所有这些病变都被认为是某种形式的动脉硬化。我们认为这是正确的，因为它允许广泛地使用动脉硬化一词，代表一组病变，而不是单个组织学变化。然而，这个词的这种通用用法并不吸引所有人，因为仍然有这样的人将其使用限制在其起源模式或其建筑特征的独特类型上。然而，仍然有少数人在仔细调查了这个问题后，只能看到一个致病因素。如此多的不同药剂已被证明与人类病变有关或通过实验手段，我们再也不能否认不同状态或物质的有害影响。把细菌、中毒、高血压、血液性质的变化、疲劳或“磨损”对动脉的有害影响降到最低限度是徒劳的。“很明显，组织的反应也不会相同。有些是增生性的，有些是退行性的，而另一些则是选择性的。因此，我们认识到动脉的各种病变
The very many ways that have been tried to reproduce in animals lesions comparable to those found in human arteries indicate the diverse views on the causation of arteriosclerosis. In furthering such views the authors do not hesitate to proclaim the similarity of the expeiimental lesions with types of arteriosclerosis. Hence, one is soon struck by the great variety of lesions, both in the human and animal arteries, all of which are claimed to represent some form of arteriosclerosis. This we believe is not amiss, for it will permit the use of the term arteriosclerosis broadly, representing a group of lesions, and not an individual histological variety. This generic use of the term does not, however, appeal to all, for there are still such who would limit its use to a type unique in its mode of origin, or in its architectural character. There remain, however, few who after investigating the problem closely can see only one causative factor. So many different agents have been demonstrated associated in the human lesions or by experimental means that we can no longer deny the harmful effects of diverse states or substances. It is futile to minimize the harmful effect upon the arteries of bacteria, intoxications, high blood pressure, changes in the character of the blood, and fatigue or " wear and tear." Obvious it is, too, that the tissue responses will not be the same. Some are proliferative, some are degenerative, while others are selective in the tissue attacked. Thus we come to recognize a great variety of lesions of the arterial