Age-related changes in processing speed: unique contributions of cerebellar and prefrontal cortex
Age-related changes in processing speed: unique contributions of cerebellar and prefrontal cortex
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DOI：
10.3389/neuro.09.010.2010
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发表时间：
2010-03-01
影响因子：
2.9
通讯作者：
Harris, Kelly C.
中科院分区：
文献类型：
--
作者：
Eckert, Mark A.;Keren, Noam I.;Harris, Kelly C.
据推测，大脑处理速度的下降是老年人认知能力普遍变化的基础。我们使用结构协方差方法来识别假定的神经网络，这些神经网络是42名年龄从19岁到79岁的成年人与处理速度相关的年龄相关结构变化的基础。为了表征与年龄相关的灰质变化导致处理速度较慢的潜在机制，我们研究了脑小血管疾病影响与年龄相关的灰质变化和处理速度之间的关联的程度。与脑小血管疾病相关的灰质和白色物质变化的额叶模式，以及灰质和白色物质变化的小脑模式与年龄相关的处理速度下降唯一相关。这些结果表明，至少有两个不同的因素影响与年龄相关的处理速度的变化，这可能是减缓减轻脑小血管疾病和影响小脑形态下降的因素。
Age-related declines in processing speed are hypothesized to underlie the widespread changes in cognition experienced by older adults. We used a structural covariance approach to identify putative neural networks that underlie age-related structural changes associated with processing speed for 42 adults ranging in age from 19 to 79 years. To characterize a potential mechanism by which age-related gray matter changes lead to slower processing speed, we examined the extent to which cerebral small vessel disease influenced the association between age-related gray matter changes and processing speed. A frontal pattern of gray matter and white matter variation that was related to cerebral small vessel disease, as well as a cerebellar pattern of gray matter and white matter variation were uniquely related to age-related declines in processing speed. These results demonstrate that at least two distinct factors affect age-related changes in processing speed, which might be slowed by mitigating cerebral small vessel disease and factors affecting declines in cerebellar morphology.