Estrogen protects against 3-methylindole-induced olfactory loss
Estrogen protects against 3-methylindole-induced olfactory loss
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DOI：
10.1016/s0006-8993(99)01241-x
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发表时间：
1999-04-10
期刊：
影响因子：
2.9
通讯作者：
Doty, RL
中科院分区：
文献类型：
--
作者：
Dhong, HJ;Chung, SK;Doty, RL
嗅觉功能障碍是阿尔茨海默病（AD）的最初迹象之一。由于雌激素治疗可以减轻AD的认知症状，我们确定了17 β-雌二醇（E-2）是否改变了暴露于嗅觉毒物3-甲基吲哚（3-MI）的雌性大鼠的嗅觉辨别性能。12只切除卵巢的大鼠接受每天注射E-2（lmg/kg i.p.）10只每天只注射玉米油。在整个10周的测试期间，几乎每天进行感官测试，在测试期间的中途单次注射3-MI（300 mg/kg i.p.）。在每个3-MI测试前和3-MI测试后，要求大鼠进行一系列连续的更困难的气味辨别任务，直到达到<80%的表现。任务在10（-4）v/v浓度的乙酸乙酯（EA）的气味和添加到EA中的六种不同浓度的丁醇（10（-4）、10（-4.5）、10（-5.0）、10（-5.5）、10（-6.0）、10（-6.5）v/v）中的每一种的气味之间。在3-MI处理后，发现E-2处理的大鼠的表现优于油处理的大鼠的表现，并且更快地恢复到3-MI前的基线，这表明高剂量的E-2减轻了大鼠中3-MI诱导的嗅觉丧失。需要进一步的工作来确定这种现象的生理基础（C）1999年由Elsevier Science B.V.出版，保留所有权利。
Olfactory dysfunction is among the first signs of Alzheimer's disease (AD). Since estrogen therapy may mitigate the cognitive symptoms of AD, we determined whether 17 beta-estradiol (E-2) alters the olfactory discrimination performance of female rats exposed to the olfactotoxicant 3-methylindole (3-MI). Twelve ovariectomized rats received daily injections of E-2 (1 mg/kg i.p.) in corn oil and 10 received daily injections of corn oil alone. Sensory testing occurred on a near-daily basis throughout a 10-week test period, midway in which a single injection of 3-MI was administered (300 mg/kg i.p.). On each pre- and post-3-MI test day, the rats were required to perform a series of successively more difficult odor discrimination tasks until one was reached where < 80% performance was attained. The tasks were between the odor of a 10(-4) v/v concentration of ethyl acetate (EA) and the odor of each of six different concentrations of butanol added to the EA (10(-4), 10(-4.5), 10(-5.0), 10(-5.5), 10(-6.0), 10(-6.5) v/v). Following 3-MI treatment, the performance of the E-2-treated rats was found to be superior to that of the oil-treated mts and to return more quickly to the pre-3 MI baseline, suggesting that high doses of E-2 mitigate 3-MI-induced smell loss in rats. Additional work is needed to determine the physiologic basis of this phenomenon (C) 1999 Published by Elsevier Science B.V. All rights reserved.