Seizure duration determined by subdural electrode recordings in adult patients with intractable focal epilepsy.
Seizure duration determined by subdural electrode recordings in adult patients with intractable focal epilepsy.
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DOI：
10.14581/jer.11011
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发表时间：
2011-12
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影响因子：
--
通讯作者：
Seo DW
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文献类型：
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作者：
Kim D;Cho JW;Lee J;Joo EY;Hong SC;Hong SB;Seo DW
探讨癫痫发作持续时间及其与癫痫类型、癫痫综合征、癫痫聚集性的关系。我们检查了来自152名患者的1,251次癫痫发作，这些患者接受了硬膜下电极视频皮质电图监测。分析其发作持续时间、发作类型、癫痫症状和发作簇。中位发作持续时间为91.5s（4- 1016 s）。20例（13.2%）患者中有34例（2.7%）癫痫发作持续时间> 5分钟。癫痫发作持续时间与癫痫类型有显著性差异（p < 0.0001），但与癫痫综合征无显著性差异。67例（44.1%）患者出现99次发作簇。一组癫痫发作中的首次癫痫发作往往比非组癫痫发作持续时间更长（中位数98秒vs 89秒，p = 0.033）。内侧颞叶癫痫的癫痫发作持续时间显著长于新皮质叶癫痫（中位数103 s vs 87 s，p = 0.041）。mTLE组发作簇的发生率（38.0%）低于NLE组（47.1%），但差异无统计学意义。不同类型癫痫发作持续时间不同。发作聚集性在mTLE和NLE患者之间也不同，这表明不同致痫灶之间的发作产生和传播不同。这项研究对识别异常延长的癫痫发作有一定的意义。
To investigate the duration of seizures and its relationship to seizure type, epilepsy syndrome, and seizure clustering. We examined 1,251 seizures from 152 patients who underwent video-electrocorticographic monitoring with subdural electrodes. Their seizure duration, seizure types, epilepsy syndromes, and seizure clusters were analyzed. The median seizure duration was 91.5s (4–1016s). There were 34 (2.7%) seizures lasting > 5 minutes in 20 (13.2%) patients. There was a significant difference in seizure duration according to seizure types (p < 0.0001), but not to epilepsy syndromes. There were 99 seizure clusters in 67 (44.1%) patients. The first seizure in a cluster of seizures tended to last longer than non-cluster seizures (median 98s versus 89s, p = 0.033). Seizure duration was significantly longer in mesial temporal lobe epilepsy than in neocortical lobe epilepsy (median 103s versus 87s, p = 0.041). Rate of seizure cluster was lower in mTLE (38.0%) than in NLE (47.1%), but this difference was not significant. Seizure durations were different among seizure types. Seizure clustering also differ between patients with mTLE and those with NLE, which suggests different seizure generation and propagation among different epileptogenic foci. This study has implications for the identification of abnormally prolonged seizures.