The nuclear lamina and its proposed roles in tumorigenesis: Projection on the hematologic malignancies and future targeted therapy
The nuclear lamina and its proposed roles in tumorigenesis: Projection on the hematologic malignancies and future targeted therapy
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DOI：
10.1016/j.jsb.2006.02.016
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发表时间：
2006-08-01
影响因子：
3
通讯作者：
Gruenbaum, Yosef
中科院分区：
文献类型：
--
作者：
Prokocimer, Miron;Margalit, Ayelet;Gruenbaum, Yosef
核层是由核层蛋白丝和核层蛋白相关蛋白组成的网状结构，位于核膜和外周染色质之间。核层参与许多核功能，包括维持核形状、决定核定位、组织染色质和调节细胞周期、DNA复制、转录、细胞分化、凋亡和衰老。核层蛋白及其相关蛋白组成的改变目前正在成为恶性转化、肿瘤增殖和进展的一个额外事件，从而为未来的抗癌治疗确定了潜在的新靶点。在这里。，我们回顾了目前对血液恶性肿瘤细胞中层压蛋白表达模式的了解，并概述了核层压蛋白在异染色质组织、细胞凋亡和衰老中的作用，特别强调了与癌症发展的相关性。(c) 2006爱思唯尔公司版权所有。
The nuclear lamina, a network of lamin filaments and lamin-associated proteins, is located between the inner nuclear membrane and the peripheral chromatin. The nuclear lamina is involved in numerous nuclear functions including maintaining nuclear shape, determining nuclear positioning, organizing chromatin and regulating the cell cycle, DNA replication, transcription, cell differentiation, apoptosis, and aging. Alterations in the composition of nuclear lamins and their associated proteins are currently emerging as an additional event involved in malignant transformation, tumor propagation and progression, thus identifying potential novel targets for future anti-cancer therapy. Here., we review the current knowledge on lamin expression patterns in cells of hematologic malignancies and give an overview on the roles of the nuclear lamina proteins in heterochromatin organization, apoptosis, and aging with special emphasis on the relevance in cancer development. (c) 2006 Elsevier Inc. All rights reserved.