Subgroup analysis reveals higher reliability of the new comprehensive evaluation of Global Initiative for Chronic Obstructive Lung Disease 2019.
Subgroup analysis reveals higher reliability of the new comprehensive evaluation of Global Initiative for Chronic Obstructive Lung Disease 2019.
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亚组分析显示2019年全球慢性阻塞性肺病倡议新综合评估的可靠性更高
DOI：
10.1038/s41598-021-04756-w
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发表时间：
2022-01-14
影响因子：
4.6
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Dai Z;Zeng H;Cui Y;Chen P;Chen Y
目的了解湖南省门诊慢性阻塞性肺疾病（COPD）患者的病情严重程度，并采用亚组分析法评价全球慢性阻塞性肺疾病倡议（GOLD）新的综合评价方法的可靠性。根据GOLD 2016和2019综合评估，将来自中国湖南省12家医疗中心的COPD门诊患者分层为A-D组，D组患者进一步分层为D1-D3亚组。比较各组的人口统计学、临床特征和药物治疗。根据GOLD 2016，在1017例COPD门诊患者中，A至D组和D1至D3亚组的分布分别为41例（4.0%）、249例（24.5%）、17例（1.7%）、710例（69.8%）和214例（30.2%）、204例（28.7%）、292例（41.1%）。在与A-D组相关的人口统计学和临床特征方面，COPD评估试验（CAT）、改良英国医学研究理事会（mMRC）、临床COPD问卷（CCQ）、年龄、BMI、教育水平、吸烟史、合并症、慢性支气管炎/肺气肿病程、前一年急性加重/住院次数、治疗方案、1秒用力呼气容积（FEV 1）%预测值和FEV 1/用力肺活量（FVC）（p < 0.01）。此外，根据GOLD 2019，C-D组中重新分组至A-B组的部分患者均为C1和D1亚组。将D1亚组与B组、D2亚组和D3亚组进行比较，发现根据GOLD 2016，D1亚组的人口统计学、临床特征和用药最接近B组（p < 0.01）。湖南省门诊COPD患者的病情严重程度在B、D组中更为明显，A-D组患者的人口统计学、临床特征和药物治疗不同。亚组分析可以在一定程度上解释GOLD 2019新的综合评估比GOLD 2016更可靠。
To estimate the severity of the disease in outpatients with chronic obstructive pulmonary disease (COPD) in Hunan Province, China and use the subgroup analysis to evaluate the reliability of the new comprehensive evaluation of Global Initiative for Chronic Obstructive Lung Disease (GOLD). COPD outpatients from 12 medical centers in Hunan Province, China were stratified into groups A–D, and group D patients were further stratified into subgroups D1–D3 according to the GOLD 2016 and 2019 comprehensive assessment. Demography, clinical characteristics and medications were compared among groups. In 1017 COPD outpatients, the distribution from group A to D and subgroup D1 to D3 was 41 (4.0%), 249 (24.5%), 17 (1.7%), 710 (69.8%) and 214 (30.2%), 204 (28.7%), 292 (41.1%), according to GOLD 2016. In terms of demographic and clinical characteristics related to A–D groups, there was a significant difference in COPD assessment test (CAT), modified Medical British Research Council (mMRC), the clinical COPD questionnaire(CCQ), age, BMI, education level, smoking history, comorbidities, the course of chronic bronchitis/emphysema, number of exacerbations/hospitalisations in the previous year, treatment protocols, forced expiratory volume in one second (FEV1) % predicted, and FEV1/forced vital capacity (FVC) (p < 0.01). Furthermore, some patients in groups C–D regrouped to groups A–B were all C1 and D1 subgroups according to GOLD 2019. Comparing subgroup D1 with group B, subgroup D2 and subgroup D3, it was found that the demography, clinical characteristics and medications of subgroup D1 were the closest to group B, according to GOLD 2016 (p < 0.01). The disease severity of outpatients with COPD in Hunan Province was more pronounced in group B and D and patients in groups A–D had different demography, clinical characteristics and medications. Subgroup analysis can explain to a certain extent that GOLD2019’s new comprehensive assessment is more reliable than GOLD 2016.
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影响因子：
9.6
作者：
Suissa, Samy;Dell'Aniello, Sophie;Ernst, Pierre
通讯作者：
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影响因子：
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DOI：
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24.7
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DOI：
10.1164/rccm.201207-1299oc
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2012-11-15
影响因子：
24.7
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