An effect of context on saccade-related behavior and brain activity
An effect of context on saccade-related behavior and brain activity
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DOI：
10.1016/j.neuroimage.2007.03.023
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发表时间：
2007-07-01
期刊：
影响因子：
5.7
通讯作者：
McDowell, Jennifer E.
中科院分区：
文献类型：
--
作者：
Dyckman, Kara A.;Camchong, Jazmin;McDowell, Jennifer E.
本研究评估了背景对眼跳任务中行为和大脑活动的影响。在36名参与者完成三个区块设计的运行时收集了FMRI和眼动数据：（1）注视与亲扫视交替，（2）注视与反扫视交替，以及（3）亲扫视与反扫视交替。两个任务相关的数据驱动的回归，使用独立成分分析，被用于GLM分析。在单次扫视（运行1和2）和混合扫视（运行3）条件下，比较了与反扫视和促扫视相关的脑活动。在先前的研究中，与反扫视一致相关的大脑区域，包括纹状体、丘脑、楔叶、楔前叶、外侧和内侧额叶眼野（FEF）、补充眼野（SEF）和前额叶皮层（PFC），在注视/反扫视期间与注视/前扫视运行相比，显示出显著更大的信号变化百分比。然而，在正/反运行期间，只有楔前叶，SEF和FEF在反扫视试验期间显示出更大的激活。这清楚地表明，与扫视相关的神经回路受到上下文的影响。行为结果表明，在眼跳任务的性能也受到影响的背景。参与者在反试验之后的赞成试验中犯的方向错误比在固定之后的赞成试验中犯的方向错误要多。这项研究的结果表明，楔前叶，SEF和FEE，这表明在两个比较的抗扫视相关的活动，可能是更重要的支持这种复杂的行为反应。其他大脑区域，如PFC，然而，这表明反眼跳相关的活动，在只有单一的任务比较，可能更多地参与反应选择和/或上下文更新。(c)2007爱思唯尔公司All rights reserved.
The present study evaluated the effect of context on behavior and brain activity during saccade tasks. FMRI and eye movement data were collected while 36 participants completed three runs in a block design: (1) fixation alternating with pro-saccades, (2) fixation alternating with anti-saccades, and (3) pro-alternating with anti-saccades. Two task-related data-driven regressors, identified using independent component analysis, were used in GLM analyses. Brain activity associated with anti- and pro-saccades were compared under both single (runs 1 and 2) and mixed saccade (run 3) conditions. Brain areas consistently associated with anti-saccades in previous studies, including striatum, thalamus, cuneus, precuneus, lateral and medial frontal eye fields (FEF), supplementary eye fields (SEF), and prefrontal cortex (PFC) showed significantly greater percent signal change during the fixation/anti-compared with the fixation/pro-saccade run. During the pro/anti run, however, only precuneus, SEF and FEF showed greater activation during the anti-saccade trials. This is a clear demonstration that the saccade-related neural circuitry is affected by context. Behavioral results suggest that performance on saccade tasks is also affected by context. Participants made more direction errors on pro-trials that followed anti-trials than on pro-trials that followed fixation. Results from this study indicate that precuneus, SEF and FEE, which showed anti-saccade-related activity during both comparisons, may be more important for supporting this complex behavioral response. Other brain regions, such as PFC, however, which showed anti-saccade-related activity during only the single task comparison, may be more involved in response selection and/or context updating. (c) 2007 Elsevier Inc. All rights reserved.