Great expectations: protein tyrosine phosphatases in cell regulation.
Great expectations: protein tyrosine phosphatases in cell regulation.
复制标题
远大的期望：蛋白质酪氨酸磷酸酶在细胞调节中的作用。
DOI：
10.1016/0304-419x(92)90007-l
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Brautigan,DL
中科院分区：
文献类型：
--
作者：
Brautigan,DL
1 .蛋白磷酸化和信号转导蛋白激酶（Protein kinase）将磷酸基（pht）从ATP诱导到胞内蛋白（Protein phosphorylation）是胞外信号转导的基本机制。肾上腺素能激素激活糖原降解的研究首次提供了蛋白磷酸化和序列激酶在“级联”中作为调节机制的例子（参见参考文献中的评论）。1、2)。该系统在多年后仍然是一个占主导地位的范例。在细胞生长和分化的控制中，细胞外信号是
I. Protein phosphorylation and signal transduc| ion lntn) duction of pht) sphoryl groups fror,: ATP onto intracellular proteins by protein kinases (protein phosphorylation) is recognized as a fundamental mechanism for the transduction of extracellular signals. Pit)-neering research on the activation of glycogen degradation in response to adrenergic hormones provided the first examples of protein phosphorylation and sequential kinases in'cascades' as regulatory mechanisms (see reviews in Ref~;. 1, 2). The system remains after many years as a dominant paradigm. In the control of cell growth and differentiation, the extracellular signals are