Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease.
Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease.
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DOI：
10.1371/journal.pone.0100395
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Imoto M
中科院分区：
文献类型：
--
作者：
Fujimaki T;Saiki S;Tashiro E;Yamada D;Kitagawa M;Hattori N;Imoto M
在从传统中草药库中筛选抗帕金森病药物的过程中，我们发现Choi-joki-to和Daio-kanzo-to的提取物对MPP+诱导的细胞死亡具有保护作用。因为Choi-joki-to和Daio-kanzo-to通常含有甘草属植物，所以我们从甘草中分离出甘草吡喃香豆素(LPC)和甘草醛(GCR)作为有效的神经保护成分。LPC和GCR可明显阻断MPP+诱导的PC12D细胞死亡和线粒体膜电位消失，这种作用由JNK介导。LPC和GCR通过抑制ROS的产生而抑制MPP+诱导的JNK活化，从而抑制MPP+诱导的神经元性PC12D细胞死亡。这些结果表明，由Choi-joki-to和Daio-kanzo-to衍生的LPC和GCR有望成为未来帕金森病治疗的药物先导。
In the course of screening for the anti-Parkinsonian drugs from a library of traditional herbal medicines, we found that the extracts of choi-joki-to and daio-kanzo-to protected cells from MPP+-induced cell death. Because choi-joki-to and daio-kanzo-to commonly contain the genus Glycyrrhiza, we isolated licopyranocoumarin (LPC) and glycyrurol (GCR) as potent neuroprotective principals from Glycyrrhiza. LPC and GCR markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane potential, which were mediated by JNK. LPC and GCR inhibited MPP+-induced JNK activation through the suppression of reactive oxygen species (ROS) generation, thereby inhibiting MPP+-induced neuronal PC12D cell death. These results indicated that LPC and GCR derived from choi-joki-to and daio-kanzo-to would be promising drug leads for PD treatment in the future.
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