Antimicrobial susceptibility of Gram-negative ESKAPE pathogens isolated from hospitalized patients with intra-abdominal and urinary tract infections in Asia-Pacific countries: SMART 2013-2015
Antimicrobial susceptibility of Gram-negative ESKAPE pathogens isolated from hospitalized patients with intra-abdominal and urinary tract infections in Asia-Pacific countries: SMART 2013-2015
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DOI：
10.1099/jmm.0.000421
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发表时间：
2017-01-01
影响因子：
3
通讯作者：
Sahm, Daniel F.
中科院分区：
文献类型：
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作者：
Karlowsky, James A.;Hoban, Daryl J.;Sahm, Daniel F.
革兰氏阴性ESKAPE病原体（肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌和肠杆菌属）是导致全球耐药性感染增加的原因。我们使用临床和实验室标准协会肉汤微量稀释法，测定了2013年至2015年11个亚太国家/地区腹腔内感染（IAI）（n = 3052）和尿路感染（UTI）（n = 1088）住院患者中分离的革兰氏阴性ESKAPE病原体对8种胃肠外抗菌药物的体外敏感性。对阿米卡星（98.3，96.4%）、亚胺培南（97.1，95.5%）和厄他培南（95.3，93.2%）敏感率最高.肺炎的IAI和UTI，而先进的一代头孢菌素的敏感性< 4，
Gram-negative ESKAPE pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) are responsible for increases in antimicrobial-resistant infections worldwide. We determined in vitro susceptibilities to eight parenteral antimicrobial agents using Clinical and Laboratory Standards Institute broth microdilution methodology for Gram-negative ESKAPE pathogens isolated from hospitalized patients with intra-abdominal infections (IAIs) (n = 3052) and urinary tract infections (UTIs) (n = 1088) in 11 Asia-Pacific countries/regions from 2013 to 2015. Amikacin (98.3, 96.4 %), imipenem (97.1, 95.5 %) and ertapenem (95.3, 93.2 %) demonstrated the highest rates of susceptibility for isolates of K. pneumoniae from IAI and UTI, respectively, whereas susceptibility to advanced-generation cephalosporins was < 4 and