Relation of inflammation to peripheral arterial disease in the National Health and Nutrition Examination Survey, 1999-2002
Relation of inflammation to peripheral arterial disease in the National Health and Nutrition Examination Survey, 1999-2002
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DOI：
10.1016/j.amjcard.2005.07.067
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发表时间：
2005-12-01
影响因子：
2.8
通讯作者：
He, J
中科院分区：
文献类型：
--
作者：
Wildman, RP;Muntner, P;He, J
炎症与外周动脉疾病（PAD）之间的关系尚不清楚。这项研究在美国成年人口的横截面、全国代表性样本中检验了这种关系及其在重要亚组中的一致性。在 1999-2002 年国家健康和营养检查调查中，对 4,787 名 40 岁以上参与者的样本进行了 C 反应蛋白 (CRP)、纤维蛋白原、白细胞计数和 PAD 的评估。 PAD 定义为踝臂血压指数 < 0.9。炎症标志物与 PAD 之间存在分级关系。与 CRP、纤维蛋白原和白细胞计数最高与最低四分位数相关的 PAD 多变量调整优势比分别为 2.14（95% 置信区间 [CI] 1.41 至 3.25）、2.49（95% CI 1.27 至 4.85）和 1.67（95% CI 0.84 至 3.31）（每个 p 趋势四分位数 < 0.05）。在性别、肥胖和糖尿病亚组中，炎症与 PAD 之间的关联相似。然而，非西班牙裔黑人最高 CRP 四分位数与最低 3 个四分位数的 PAD 比值比为 3.10（95% CI 1.76 至 5.45），非西班牙裔白人为 1.50（95% CI 0.98 至 2.28），墨西哥裔美国人为 1.11（95% CI 0.57 至 2.17） 40 至 54 岁的患者为 2.01（95% CI 1.13 至 3.58），年龄 40 至 54 岁的患者为 2.01（95% CI 1.13 至 3.58），70 岁以上的患者为 0.98（95% CI 0.65 至 1.48）（p 相互作用 = 0.049）和 5.59（95% CI 1.82 至 17.17）。 0.018）。目前吸烟者的纤维蛋白原最高四分位数与最低 3 个四分位数的 PAD 比值比为 3.26（95% CI 1.69 至 6.28），而从不吸烟者则为 0.83（95% CI 0.51 至 1.35）（p 交互作用 = 0.006）。总之，在一般美国成年人群中，炎症与 PAD 独立相关。 (c) 2005 Elsevier Inc. 保留所有权利。
The relation between inflammation and peripheral arterial disease (PAD) is not well characterized. This study examined this relation and its consistency across important subgroups in a cross-sectional, nationally representative sample of the adult United States population. C-reactive protein (CRP), fibrinogen, leukocyte count, and PAD were assessed in a sample of 4,787 participants aged >= 40 years in the National Health and Nutrition Examination Survey 1999-2002. PAD was defined as an ankle-brachial blood pressure index < 0.9. Graded relations were present between inflammatory markers and PAD. The multivariate adjusted odds ratios of PAD associated with the highest versus the lowest quartile of CRP, fibrinogen, and leukocyte count were 2.14 (95% confidence interval [CI] 1.41 to 3.25), 2.49 (95% CI 1.27 to 4.85), and 1.67 (95% Cl 0.84 to 3.31), respectively (each p trend < 0.05 across quartiles). Associations between inflammation and PAD were similar across gender, obesity, and diabetic subgroups. However, the odds ratios of PAD for the highest CRP quartile versus the 3 lowest quartiles were 3.10 (95% Cl 1.76 to 5.45) for non-Hispanic blacks versus 1.50 (95% CI 0.98 to 2.28) for non-Hispanic whites and 1.11 (95% CI 0.57 to 2.17) for Mexican Americans (p interaction = 0.049) and 5.59 (95% CI 1.82 to 17.17) for patients aged 40 to 54 years versus 2.01 (95% Cl 1.13 to 3.58) for patients aged 55 to 69 years and 0.98 (95% CI 0.65, to 1.48) for patients aged >= 70 years (p interaction = 0.018). Odds ratios of PAD for the highest fibrinogen quartile versus the lowest 3 quartiles were 3.26 (95% CI 1.69 to 6.28) for current smokers versus 0.83 (95% CI 0.51 to 1.35) for never smokers (p interaction = 0.006). In conclusion, in the general United States adult population, inflammation is independently associated with PAD. (c) 2005 Elsevier Inc. All rights reserved.