Glycolic acid modulates the mechanical property and degradation of poly(glycerol, sebacate, glycolic acid)
Glycolic acid modulates the mechanical property and degradation of poly(glycerol, sebacate, glycolic acid)
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乙醇酸调节聚（甘油、癸二酸酯、乙醇酸）的机械性能和降解
DOI：
10.1002/jbm.a.32370
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发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Dong, De-Li
中科院分区：
文献类型：
--
作者：
Sun, Zhi-Jie;Wu, Lan;Dong, De-Li
开发具有可控降解性能的生物可降解材料有利于各种应用。聚（甘油-癸二酸酯）（PGS）是一种很有前途的生物材料，因此我们合成了一系列甘油、癸二酸酯和乙醇酸的摩尔比为1：10、1：2：0.2、1：2：0.4、1：2：0.6、1：2：1的聚（甘油、癸二酸酯和乙醇酸）（PGSG），以阐明掺杂乙醇酸对降解速率和力学性能的影响。不同乙醇酸掺杂的聚合物的微观结构不同。当羟基乙酸的比例为0.2时，PGSG呈现出完整的有序度，而羟基乙酸的比例为0，0.4，0.6和1时，PGSG呈现出温和的相分离结构。PGSG熔融峰的数目、Δ H（m）和温度随着掺杂的乙醇酸的比例的增加而趋于降低。体外和体内降解实验表明，PGSG与乙醇酸的比例为0.2时降解速率最慢，但在比例为0、0.4和0.6时，降解速率随乙醇酸的增加而增加。所有PGSG样品均表现出良好的组织反应和抗凝作用。结果表明，羟基乙酸的掺杂可以调节PGS的微观结构和交联程度，从而控制PGS的降解速率。(C)2009 Wiley Periodicals，Inc. J Biomed Mater Res 92A：332-339，2010
The development of biodegradable materials with controllable degradation properties is beneficial for a variety of applications. Poly(glycerol-sebacate) (PGS) is a promising candidate of biomaterials; so we synthesize a series of poly(glycerol, sebacate, glycolic acid) (PGSG) with 1:10, 1:2:0.2, 1:2:0.4, 1:2:0.6, 1:2:1 mole ratio of glycerol, sebacate, and glycolic acid to elucidate the relation of doped glycolic acid to the degradation rate and mechanical properties. The microstructures of the polymers with different doping of glycolic acid were dissimilar. PGSG with glycolic acid in the ratio of 0.2 displayed an integral degree of ordering, different to those with glycolic acid in the ratio of 0, 0.4, 0.6, and 1, which showed mild phase separation structure. The number, Delta H(m), and temperature of the PGSG melting peaks tended to decrease with the increasing ratio of doped glycolic acid. In vitro and in vivo degradation tests showed that the degradation rate of PGSG with glycolic acid in the ratio of 0.2 was slowest, but in the ratio range of 0, 0.4, and 0.6, the degradation rate increased with the increase of glycolic acid. All PGSG samples displayed good tissue response and anticoagulant effects. Our data suggest that doping glycolic acid can modulate the microstructure and degree of crosslinking of PGS, thereby control the degradation rate of PGS. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 92A: 332-339, 2010