Decreased plasma adiponectin concentrations in nondiabetic women with elevated homeostasis model assessment ratios
Decreased plasma adiponectin concentrations in nondiabetic women with elevated homeostasis model assessment ratios
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DOI：
10.1530/eje.0.1480343
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发表时间：
2003-03-01
影响因子：
5.8
通讯作者：
Maruoka, S
中科院分区：
文献类型：
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作者：
Matsubara, M;Katayose, S;Maruoka, S
目的：脂肪细胞衍生蛋白脂联素是否独立于肥胖和糖尿病状态的影响与胰岛素抵抗有关是一个重要的问题。在一项对486名日本非糖尿病女性进行的横断面研究中，我们探索了计算的胰岛素抵抗(稳态模型评估比率(HOMA-R))和用验证的三明治ELISA测定的脂联素水平之间的关系。设计和方法：所有参与者被分成三个等级的HOMA-R(类似于-lt；1.5，小于或等于<；3.0，小于或等于-lt；3.0，小于或等于)，并用单因素方差分析检验连续变量之间的差异。用双因素方差分析来确定HOMA-R患者的血浆脂联素水平与几个分层参数之间的可能关系。以HOMA-R或空腹血清胰岛素为因变量，以舒张压(BP)、体重指数(BMI)、血清甘油三酯(TG)、瘦素、脂联素为自变量进行多元回归分析。结果：高HOMA-R组较低HOMA-R组平均血浆脂联素降低(Mean+/-SEM.6.2+/-0.6vs 9.2+/-0.3mug/ml，P<；0.001)，调整后的体脂质量为千克或百分比(0.31±0.04vs0.69+/-0.03，0.18+/-0.02vs0.34+/-10.01，P均为0.001)。HOMA-R与脂联素水平呈负相关(r=-0.37，P<；0.001)，校正BFM后呈负相关(r=-0.49，-0.46，P均为0.001)。在调整年龄、舒张压、体重指数和血清甘油三酯的协变量后。HOMA-R与脂联素/BFM(Kg)呈显著正相关。在多元回归模型中，脂联素和瘦素都是HOMA-R或空腹胰岛素的显著决定因素。结论：在非糖尿病患者中，脂联素与胰岛素抵抗呈负相关，与年龄、肥胖和血脂无关。由于脂联素被认为具有抗动脉粥样硬化的作用，低脂联素血症的存在可能使人易患动脉粥样硬化，并可能在胰岛素抵抗的情况下促进动脉粥样硬化的形成。
Objective: Whether the adipocyte-derived protein adiponectin is associated with insulin resistance independently of the effects of adiposity and the diabetic state is an important question. We explored, in a cross-sectional study of 486 Japanese nondiabetic women, the relationship between the calculated insulin resistance (homeostasis model assessment ratio (HOMA-R)) and adiponectin levels determined using a validated sandwich ELISA.Design and methods: All participants were stratified into tertiles for HOMA-R (similar to < 1.5, 1.5 less than or equal to similar to < 3.0, 3.0 less than or equal to similar to) and the differences across tertiles of continuous variables were tested with ANOVA. Two-way ANOVA was used to determine possible relationships for plasma adiponectin between tertiles of HOMA-R and several stratified parameters. Multiple regression analyses were performed with HOMA-R or fasting serum insulin as dependent variable, and diastolic blood pressure (BP), body mass index (BMI), serum triglyceride (TG), leptin and adiponectin as independent determinants.Results: Mean plasma adiponectin in the high HOMA-R group decreased compared with that in the low HOMA-R group both before (mean +/- S.E.M. 6.2 +/- 0.6 vs 9.2 +/- 0.3 mug/ml, P < 0.001) and after adjustment for body fat mass (BFM) as kg or percent (0.31 +/- 0.04 vs 0.69 +/- 0.03, 0.18 +/- 0.02 vs 0.34 +/- 10.01, both P < 0.001). HOMA-R was inversely associated with adiponectin levels both before (r = -0.37, P < 0.001) and after adjustment for BFM (r = -0.49, - 0.46, both P < 0.001). After covariate adjustment for age, diastolic BE BMI and serum TG. HOMA-R retained a significant correlation with adiponectin/BFM (kg). Both adiponectin and leptin were the significant determinants of HOMA-R or fasting insulin in multiple regression models.Conclusions: Adiponectin was inversely associated with insulin resistance in nondiabetic subjects, independently from age, BE adiposity and serum lipids. Because adiponectin is thought to have an anti-atherogenic action, the presence of hypoadiponectinemia may predispose subjects to atherosclerosis, and may progress the atherogenesis in insulin resistance.