Bioactive Polymeric Materials for Tissue Repair.
Bioactive Polymeric Materials for Tissue Repair.
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DOI：
10.3390/jfb8010004
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发表时间：
2017-01-26
影响因子：
4.8
通讯作者：
Skrtic D
中科院分区：
文献类型：
--
作者：
Bienek DR;Tutak W;Skrtic D
基于磷酸钙的生物活性聚合物材料由于其良好的生物相容性而对硬组织修复具有巨大的吸引力。基于无定形磷酸钙 (ACP) 的产品还可以防止不必要的脱矿质，并积极支持硬组织矿物质的再生。在过去的二十年里，我们的小组一直在研究 ACP 聚合物复合材料的结构/组成/性能关系。在这里，我们介绍了 ACP 在聚合物基体中的分散情况，以及树脂的微调会影响 ACP 聚合物复合材料的物理化学、机械和生物性能。这些研究说明了填料/树脂界面和单体/聚合物分子结构如何影响材料的关键性能，例如离子释放和机械强度。我们还提供了 ACP 复合材料在暴露于代表口腔环境条件的加速酸性挑战时的再矿化功效的证据。 ACP 的用途最近已扩展到包括喷枪作为制造纳米纤维支架的平台技术。这些研究重点评估将 ACP 掺入各种聚合物纤维的可行性，还包括纳米纤维中生物活性钙和磷酸根离子的释放动力学，并评估聚合物 ACP 纤维网络的生物相关性。我们还讨论了未来将现有 ACP 支架集成到精准医学领域使用的治疗输送系统中的潜力。
Bioactive polymeric materials based on calcium phosphates have tremendous appeal for hard tissue repair because of their well-documented biocompatibility. Amorphous calcium phosphate (ACP)-based ones additionally protect against unwanted demineralization and actively support regeneration of hard tissue minerals. Our group has been investigating the structure/composition/property relationships of ACP polymeric composites for the last two decades. Here, we present ACP’s dispersion in a polymer matrix and the fine-tuning of the resin affects the physicochemical, mechanical, and biological properties of ACP polymeric composites. These studies illustrate how the filler/resin interface and monomer/polymer molecular structure affect the material’s critical properties, such as ion release and mechanical strength. We also present evidence of the remineralization efficacy of ACP composites when exposed to accelerated acidic challenges representative of oral environment conditions. The utility of ACP has recently been extended to include airbrushing as a platform technology for fabrication of nanofiber scaffolds. These studies, focused on assessing the feasibility of incorporating ACP into various polymer fibers, also included the release kinetics of bioactive calcium and phosphate ions from nanofibers and evaluate the biorelevance of the polymeric ACP fiber networks. We also discuss the potential for future integration of the existing ACP scaffolds into therapeutic delivery systems used in the precision medicine field.