CONTROLLING CARDIAC CHAOS
CONTROLLING CARDIAC CHAOS
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DOI：
10.1126/science.1519060
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发表时间：
1992-08-28
期刊：
影响因子：
56.9
通讯作者：
WEISS, JN
中科院分区：
文献类型：
--
作者：
GARFINKEL, A;SPANO, ML;WEISS, JN
混沌系统对初始条件的极端敏感性使其不稳定和不可预测。然而，同样的敏感性也使它们极易受到控制，前提是可以实时分析正在形成的混乱，然后利用分析结果进行小规模的控制干预。此策略已被用于稳定药物瓦巴因引起的兔心室心律失常。通过在混沌理论确定的不规则时间对心脏进行电刺激，心律失常转化为周期性跳动。
The extreme sensitivity to initial conditions that chaotic systems display makes them unstable and unpredictable. Yet that same sensitivity also makes them highly susceptible to control, provided that the developing chaos can be analyzed in real time and that analysis is then used to make small control interventions. This strategy has been used here to stabilize cardiac arrhythmias induced by the drug ouabain in rabbit ventricle. By administering electrical stimuli to the heart at irregular times determined by chaos theory, the arrhythmia was converted to periodic beating.