Serum relaxin as a diagnostic and prognostic marker in patients with epithelial ovarian cancer
Serum relaxin as a diagnostic and prognostic marker in patients with epithelial ovarian cancer
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DOI：
10.3233/cbm-170278
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发表时间：
2018-01-01
影响因子：
3.1
通讯作者：
Lv, Yingpin
中科院分区：
文献类型：
--
作者：
Guo, Xiaojing;Liu, Yujie;Lv, Yingpin
背景与目的：松弛素是一种短循环肽类激素。本研究的目的是了解松弛素在上皮性卵巢癌（EOC）的进展中的作用，并评估其诊断和预后的意义。方法：共124例EOC患者，46例良性卵巢疾病，和50名健康对照。ELISA法测定血清松弛素水平。采用卡方检验分析血清松弛素水平与各临床病理参数之间的关系。使用Kaplan-Meier方法绘制存活曲线。使用对数秩检验比较不同组之间生存率的统计学差异。结果：卵巢上皮性癌患者血清松弛素水平显著高于卵巢良性疾病组和健康对照组（P <0.01），卵巢上皮性癌患者血清松弛素水平显著高于健康对照组（P < 0.01）。血清松弛素水平与FIGO分期、淋巴结转移、肿瘤可切除性、患者生存期、化疗及肿瘤复发有关（p < 0.05）。Kaplan-meier法分析显示，血清松弛素水平高的患者总生存时间明显短于血清松弛素水平低的患者（P < 0.01）。在多变量分析沿着与临床预后参数，血清松弛素被确定为一个独立的不利预后变量survival.CONCLUSIONS：这些结果表明，血清松弛素可能是一个临床有用的指标EOC患者的诊断和预后评估。
BACKGROUND AND AIM: Relaxin is a short circulating peptide hormone. The aim of this study was to understand the role of relaxin in progression of epithelial ovarian cancer (EOC) and to assess its diagnostic and prognostic significance.METHODS: A total of 124 patients with EOC, 46 patients with benign ovarian diseases, and 50 healthy controls were recruited. Serum levels of relaxin were determined by ELISA method. The relationship between serum relaxin level and each of the clinicopathological parameters was analyzed using the chi(2) test. Survival curves were plotted using the Kaplan-Meier method. The statistical difference in survival between the different groups was compared using the log-rank test. Survival correlation with the prognostic factors was further investigated by multivariate analysis using the Cox proportional hazards model with backward stepwise likelihood ratio.RESULTS: The results showed that serum relaxin level was significantly higher in patients with EOC than those with benign ovarian diseases and healthy controls (p < 0.01). Serum relaxin level was associated with FIGO stage, lymph node metastasis, tumor resectability, survival of the patients, chemotherapy and tumor recurrence (p < 0.05). Analysis using the Kaplan-meier method indicated that patients with high serum relaxin had significantly shorter overall survival time than those with low relaxin (p < 0.01). In a multivariate analysis along with clinical prognostic parameters, serum relaxin was identified as an independent adverse prognostic variable for survival.CONCLUSIONS: These results indicated that serum relaxin may be a clinically useful indicator for diagnostic and prognostic evaluation in EOC patients.