Effect of processing parameters on the properties of peptide-containing PLGA microspheres
Effect of processing parameters on the properties of peptide-containing PLGA microspheres
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DOI：
10.3109/02652049709015330
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发表时间：
1997-03-01
影响因子：
3.9
通讯作者：
DeLuca, PP
中科院分区：
文献类型：
--
作者：
Jeyanthi, R;Mehta, RC;DeLuca, PP
研究了制备工艺参数对鲑鱼降钙素（sCT）生物可降解微球理化性质的影响。微球的尺寸随着聚合物溶液的粘度的增加而增加。甲醇和肽在分散相中的浓度具有最明显的影响，其组合引起外部和内部孔隙度。在甲醇存在下增加sCT增加了表面积和孔隙率。表面积也随着聚合物分子量的降低而增加。在较高的分散相体积与连续相体积的比率下，表面积和表面孔隙率较高并且粒度较低。因此，微球的物理化学性质可以通过改变加工参数而容易地改变，从而允许形成具有一系列性质的微球。微球可用于评价性质与最终体内性能之间的关系。
The physico-chemical properties of biodegradable polylactide-co-glycolide (PLGA) microspheres containing the peptide salmon calcitonin (sCT) were affected by the processing parameters. The microsphere size increased with an increase in the viscosity of the polymer solution. Concentration of methanol and peptide in the dispersed phase had the most discernible effects with the combination causing external and internal porosity. Increasing sCT in the presence of methanol increased the surface area and porosity. The surface area also increased as the molecular weight of the polymer was decreased. At higher ratios of the dispersed phase volume to the continuous phase volume, the surface area and surface porosity were higher and the particle size was lower. Thus, the physico-chemical properties of the microspheres can be easily altered by varying the processing parameters allowing formation of microspheres with a range of properties. The microspheres may be used to evaluate the relationship between the properties and ultimate in-vivo performance.