Synthetic Study on Tetrapetalones: Stereoselective Cyclization of N-Acyliminium Ion To Construct Substituted 1-Benzazepines
Synthetic Study on Tetrapetalones: Stereoselective Cyclization of N-Acyliminium Ion To Construct Substituted 1-Benzazepines
复制标题
四酮类化合物的合成研究：N-酰亚胺离子立体选择性环化构建取代的1-苯并氮杂
DOI：
10.1021/ol901349b
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发表时间：
2009-09-17
期刊：
影响因子：
5.2
通讯作者：
Hong, Ran
中科院分区：
文献类型：
--
作者：
Li, Cheng;Li, Xinyu;Hong, Ran
从简单的中间体伽马-羟基酰胺开始，通过高产率的六步反应可以获得复杂的抗生素四酮类四环核心的合成。成功的合成依赖于一种基于N-酰亚胺离子环化的新策略。
The synthesis of the tetracyclic core of complex antibiotic tetrapetalones has been achieved in three steps starting from the simple intermediate gamma-hydroxy amide, which can be accessed through a high-yielding six-step sequence. The successful synthesis relies on a novel strategy based on the N-acyliminium ion cyclization.