Suitable monitoring approaches to antiretroviral therapy in resource-poor settings: Setting the research agenda
Suitable monitoring approaches to antiretroviral therapy in resource-poor settings: Setting the research agenda
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DOI：
10.1086/375368
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发表时间：
2003-07-01
影响因子：
11.8
通讯作者：
Bennish, ML
中科院分区：
文献类型：
--
作者：
Kent, DM;McGrath, D;Bennish, ML
在发展中国家提供抗逆转录病毒治疗需要适当监测治疗的指导方针，包括监测治疗效果和治疗失败、药物毒性、坚持治疗以及出现耐药生物体。富裕的工业化国家制定的指导方针严重依赖于发展中国家往往无法获得的实验室测试，对于资源有限的环境可能是不可行或不合适的。即使工业化环境中常规提供的护理标准不能复制，但监测不那么严格的抗逆转录病毒治疗计划有可能降低人类免疫缺陷病毒的发病率和死亡率。需要在考虑到富国和穷国之间差异的概念和道德框架内进行研究，以确定在资源有限的环境中为人类免疫缺陷病毒携带者提供最大利益的监测战略以及使用现有技术和资源的监测战略。
The delivery of antiretroviral therapy in the developing world requires guidelines for the appropriate monitoring of therapy, including monitoring for treatment effectiveness and treatment failure, drug toxicities, adherence to therapy, and the emergence of resistant organisms. Guidelines developed in wealthy industrialized countries, which rely heavily on laboratory tests often unavailable in the developing world, may not be feasible or appropriate for resource-limited settings. Even if the standard of care routinely delivered in industrialized settings cannot be replicated, antiretroviral treatment programs with less-intense monitoring have the potential to reduce morbidity and mortality from human immunodeficiency virus. Research to identify monitoring strategies that provide the greatest benefit to those living with human immunodeficiency virus in resource-limited settings and that use the available technologies and resources needs to be conducted within a conceptual and ethical framework that takes into account differences between rich and poor countries.