HIMASTATIN, A NEW ANTITUMOR ANTIBIOTIC FROM STREPTOMYCES-HYGROSCOPICUS .1. TAXONOMY OF PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL-ACTIVITY
HIMASTATIN, A NEW ANTITUMOR ANTIBIOTIC FROM STREPTOMYCES-HYGROSCOPICUS .1. TAXONOMY OF PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL-ACTIVITY
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DOI：
10.7164/antibiotics.43.956
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发表时间：
1990-08-01
影响因子：
3.3
通讯作者：
TOMITA, K
中科院分区：
文献类型：
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作者：
LAM, KS;HESLER, GA;TOMITA, K
菌株C39108-P210-51 （ATCC 53653）是一种从印度采集的土壤样本中分离出来的放线菌，被发现可以产生一种新的抗肿瘤抗生素，称为他马他汀。通过形态学、培养和生理特征的分类研究，确定该产菌为吸湿链霉菌C39108-P210-51。他汀对革兰氏阳性菌有抗菌活性，但对革兰氏阴性菌无活性。他汀可以延长接种了P388白血病和B16黑色素瘤细胞的小鼠的寿命。
Strain C39108-P210-51 (ATCC 53653), an actinomycete isolated from a soil sample collected in India, was found to produce a new antitumor antibiotic, designated himastatin. Taxonomic studies on its morphological, cultural and physiological characteristics identified this producing strain as Streptomyces hygroscopicus C39108-P210-51. Himastatin shows antimicrobial activity against Gram-positive bacteria but it is inactive against Gram-negative bacteria. Himastatin prolongs the life span of mice inoculated with P388 leukemia and B16 melanoma cells.