Elastic properties of osteoporotic bone measured by scanning acoustic microscopy.
Elastic properties of osteoporotic bone measured by scanning acoustic microscopy.
复制标题
通过扫描声学显微镜测量骨质疏松骨的弹性特性。
DOI：
10.1016/s8756-3282(94)00013-1
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发表时间：
1995
期刊：
影响因子：
4.1
通讯作者：
Burr,DB
中科院分区：
文献类型：
--
作者：
Hasegawa,K;Turner,CH;Recker,RR;Wu,E;Burr,DB
骨质疏松性骨折是骨量减少和骨质量下降的共同作用。我们使用扫描声学显微镜，这是一种非破坏性的方法，在大约60μm的分辨率下评估骨骼弹性，以评估活检的髂骨的质量。我们比较了绝经前正常(n=10)、骨质疏松(n=20)和绝经后正常(n=10)受试者的声速和骨体积，后者与骨质疏松受试者年龄匹配。声学测量具有高度的重复性(变异系数=0.32%)。骨质疏松患者骨体积(BV/TV=13.3%)明显低于绝经前(BV/TV=22.8%，P=0.0007；BV/TV=24.8%，P=0.0004)。骨质疏松骨的声速比年龄匹配的正常骨低6.2%(p<；0.02)，但比绝经前正常妇女的骨高3.4%。骨质疏松骨的声速低于年龄匹配的正常人，提示骨质疏松涉及组织弹性的改变。然而，在绝经前正常受试者中测得的声速最低。这一意想不到的结果可能表明组织水平特性和骨骼脆性之间存在复杂的关系。
A combination of low bone mass and decreased bone quality underlies osteoporotic fracture. We used scanning acoustic microscopy, a nondestructive method for assessing bone elasticity at a resolution of about 60 μm, to estimate the quality of biopsied iliac bones. We compared the acoustic velocities and bone volumes among premenopausal normal (n = 10), osteoporotic (n = 20), and postmenopausal normal (n = 10) subjects, the latter age-matched to the osteoporotic subjects. The acoustic measurements were highly reproducible (coefficient of variation = 0.32%). Bone volume of osteoporotic subjects (BV/TV = 13.3%) was lower than that of premenopausal and age-matched normals (BV/TV = 22.8%, p = 0.0007; BV/TV = 24.8%, p = 0.0004, respectively). Acoustic velocity of osteoporotic bone was 6.2% lower than that of age-matched normal bone (p < 0.02), but 3.4% higher than that of bone from premenopausal normal women. The lower acoustic velocity of osteoporotic bone than that of age-matched normal subjects implies that osteoporosis involves altered tissue elasticity. However, the lowest acoustic velocities were measured in premenopausal normal subjects. This unexpected result may indicate a complex relationship between tissue level properties and fragility in bone.