Early detection and tracking of bulbar changes in ALS via frequent and remote speech analysis.

Early detection and tracking of bulbar changes in ALS via frequent and remote speech analysis.
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DOI:
10.1038/s41746-020-00335-x
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发表时间:
2020
影响因子:
15.2
通讯作者:
Berisha V
Berisha V
中科院分区:
医学1区
文献类型:
--
作者:
Stegmann GM;Hahn S;Liss J;Shefner J;Rutkove S;Shelton K;Duncan CJ;Berisha V

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肌萎缩侧索硬化症(ALS)的延髓恶化是一种破坏性的特征,损害了患者的沟通能力,并与生存期缩短有关。现有的临床评估眼球功能的仪器缺乏对早期变化的敏感性。在本文中,使用N = 65名ALS患者的队列,他们提供了3-9个月的定期语音样本,我们证明了通过数字收集的语音自动算法评估,可以远程检测早期语音变化并跟踪ALS的语音进展。
Bulbar deterioration in amyotrophic lateral sclerosis (ALS) is a devastating characteristic that impairs patients’ ability to communicate, and is linked to shorter survival. The existing clinical instruments for assessing bulbar function lack sensitivity to early changes. In this paper, using a cohort of N = 65 ALS patients who provided regular speech samples for 3–9 months, we demonstrated that it is possible to remotely detect early speech changes and track speech progression in ALS via automated algorithmic assessment of speech collected digitally.
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期刊: Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
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