Relative contributions of biomarkers in Alzheimer's disease.
Relative contributions of biomarkers in Alzheimer's disease.
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DOI：
10.1016/j.annepidem.2012.09.004
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发表时间：
2012-12
影响因子：
5.6
通讯作者：
Jagust, William J.
中科院分区：
文献类型：
--
作者：
Haight, Thaddeus J.;Jagust, William J.
评估阿尔茨海默病（AD）生物标志物与其对AD的潜在贡献之间的关系。从2003-2006年阿尔茨海默病神经影像学倡议（ADNI）中纵向评估了179例轻度认知障碍（MCI）患者的生物标志物和认知评估，并用于在任何给定时间检查海马体积、全脑体积和脑葡萄糖代谢对临床AD进展的联合作用，使用阿尔茨海默病评估量表-认知子量表（ADAS-Cog）。应用边际结构模型（MSM），并使用治疗权重逆概率（IPTW）估计来解释研究变量之间的时间依赖性混杂。在任何时候，人口水平的差异脑葡萄糖代谢（例如，1-标准差（SD）增加）（−1.036 95% CI：−1.608，−0.464）和海马体积（−1.537 95% CI：−2.399，−0.674）独立降低平均ADAS-Cog，而全脑体积增加1-SD则不会（0.372 95% CI：-0.283，1.027）。脑葡萄糖代谢的影响在由基线协变量定义的亚组中不同（例如，年龄），但没有观察到海马体积和脑体积的亚组效应。脑葡萄糖代谢和海马体积代表AD风险受试者的相关生物学标志物。
To assess relationships between biomarkers for Alzheimer’s Disease (AD) and their potential contributions to AD. Biomarkers and cognitive evaluations were assessed longitudinally for 179 patients with mild cognitive impairment (MCI), from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) from 2003–2006, and were used to examine, at any given time, the joint contributions of hippocampal volume, whole brain volume, and brain glucose metabolism on clinical AD progression, using the Alzheimer’s Disease Assessment Scale-Cognitive subscale (ADAS-Cog). Marginal structural models (MSMs) were applied, and inverse-probability of treatment weight (IPTW) estimation was utilized to account for time-dependent confounding between study variables. At any given time, population-level differences (e.g. 1-standard deviation (SD) increase) in brain glucose metabolism (−1.036 95% CI: −1.608, −0.464) and hippocampal volume (−1.537 95% CI: −2.399, −0.674) independently reduced mean ADAS-Cog, whereas a 1-SD increase in whole brain volume did not (0.372 95% CI: −0.283, 1.027). Effects of brain glucose metabolism differed in subgroups defined by baseline covariates (e.g., age), but no subgroup effects were observed for hippocampal volume and brain volume. Brain glucose metabolism and hippocampal volume represent relevant biological markers in subjects at risk for AD.
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影响因子：
5
作者：
Barnes, Deborah E.;Haight, Thaddeus J.;Tager, Ira B.
通讯作者：
Tager, Ira B.
影响因子：
14
作者：
通讯作者：
--
影响因子：
9.9
作者：
Jagust, W. J.;Landau, S. M.;Mathis, C. A.
通讯作者：
Mathis, C. A.
DOI：
10.1111/j.1532-5415.2011.03490.x
发表时间：
2011-08-01
影响因子：
6.3
作者：
Inaba, Michiko;White, Lon;Masaki, Kamal
通讯作者：
Masaki, Kamal
DOI：
10.1016/j.jalz.2010.03.003
发表时间：
2010-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Jagust WJ;Bandy D;Chen K;Foster NL;Landau SM;Mathis CA;Price JC;Reiman EM;Skovronsky D;Koeppe RA;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative