A Helm model for microRNA regulation in cell fate decision and conversion
A Helm model for microRNA regulation in cell fate decision and conversion
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DOI：
10.1007/s11427-013-4547-4
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发表时间：
2013-09
期刊：
影响因子：
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通讯作者：
Shu-juan Xie;Yin Zhang;Lianghu Qu;Hui Xu
中科院分区：
文献类型：
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作者：
Shu-juan Xie;Yin Zhang;Lianghu Qu;Hui Xu
microRNA（miRNAs）是一类独特的内源性小分子非编码RNA，在转录后调节基因表达。过去十年的研究已经揭示了一个反复出现的范式，其中miRNA是各种生理和病理条件下细胞行为的关键调节因子。最令人惊讶的是，最近的观察表明，miRNA已成为体细胞重编程的有力参与者，这表明这些小RNA在细胞命运设置中具有特别重要的作用。在这里，我们讨论了miRNA介导的细胞编程的可能机制（即，胚胎干细胞的发育和分化）和重编程（即，将体细胞转化为多能干细胞或其他谱系），并提供miRNA在细胞命运决定和转化中的“Helm”模型。
microRNAs (miRNAs) constitute a unique class of endogenous small non-coding RNAs that regulate gene expression post-transcriptionally. Studies over the past decade have uncovered a recurring paradigm in which miRNAs are key regulators of cellular behavior under various physiological and pathological conditions. Most surprising is the recent observation that miRNAs have emerged as competent players in somatic cell reprogramming, suggesting an especially significant role for these small RNAs in cell fate settings. Here, we discuss the possible mechanisms underlying miRNA-mediated cell programming (i.e., the development and differentiation of embryonic stem cells) and reprogramming (i.e., turning somatic cells into pluripotent stem cells or other lineages), and provide a “Helm” model of miRNAs in cell fate decision and conversion.